Cargando…

Salvianolic acid B protects against acute and chronic liver injury by inhibiting Smad2C/L phosphorylation

Salvianolic acid B (Sal B) has strong antioxidant and anti-fibrosis effects, which are related to the transforming growth factor β/Smad signaling pathway. However, how Sal B affects this antioxidant pathway and the phosphorylation (p-) of Smad2 at both the COOH-terminal (pSmad2C) and linker region (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tao, Xiang-Ming, Li, Dong, Zhang, Chong, Wen, Guang-Hua, Wu, Chao, Xu, Yuan-Yuan, Kan, Yue, Lu, Wan-Peng, Ding, Han-Yan, Yang, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903446/ https://www.ncbi.nlm.nih.gov/pubmed/33732314 http://dx.doi.org/10.3892/etm.2021.9772

Ejemplares similares

Salvianolate Protects Hepatocytes from Oxidative Stress by Attenuating Mitochondrial Injury
por: Zhao, Qiang, et al.
Publicado: (2016)

Salvianolic acid A protects against myocardial ischemia/reperfusion injury by reducing platelet activation and inflammation
por: Yuan, Xiaoling, et al.
Publicado: (2017)

Interaction of microRNA-21/145 and Smad3 domain-specific phosphorylation in hepatocellular carcinoma
por: Wang, Ji Yu, et al.
Publicado: (2017)

Salvianolic Acid A Attenuates Endoplasmic Reticulum Stress and Protects Against Cholestasis-Induced Liver Fibrosis via the SIRT1/HSF1 Pathway
por: Zhu, Jie, et al.
Publicado: (2018)

Salvianolic acid B acts against non-small cell lung cancer A549 cells via inactivation of the MAPK and Smad2/3 signaling pathways
por: Han, Guanglei, et al.
Publicado: (2022)

The Effect of Salvianolic Acid on Vascular Protection and Possible Mechanisms
por: Wu, Yalan, et al.
Publicado: (2020)

Smad3 gene C‐terminal phosphorylation site mutation aggravates CCl(4)‐induced inflammation in mice
por: Ding, Hanyan, et al.
Publicado: (2020)

BUB1 promotes proliferation of liver cancer cells by activating SMAD2 phosphorylation
por: Zhu, Li-Jing, et al.
Publicado: (2020)

Cardio-Protection of Salvianolic Acid B through Inhibition of Apoptosis Network
por: Xu, Lingling, et al.
Publicado: (2011)

Protective Effects of Salvianolic Acid A against Dextran Sodium Sulfate-Induced Acute Colitis in Rats
por: Wang, Kai, et al.
Publicado: (2018)

Differential Proteomic Analysis of Platelets Suggested Possible Signal Cascades Network in Platelets Treated with Salvianolic Acid B
por: Ma, Chao, et al.
Publicado: (2011)

Non-clinical safety evaluation of salvianolic acid A: acute, 4-week intravenous toxicities and genotoxicity evaluations
por: Yang, Ming-Yan, et al.
Publicado: (2022)

Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection
por: Ho, Jennifer Hui-Chun, et al.
Publicado: (2011)

Protective Effect of Salvianolic Acid A against N-Methyl-N-Nitrosourea-Induced Retinal Degeneration
por: Zhou, Yumei, et al.
Publicado: (2022)

Neuroprotective Effect of Salvianolic Acids against Cerebral Ischemia/Reperfusion Injury
por: Hou, Shuai, et al.
Publicado: (2016)

Salvianolic acid B protects the myelin sheath around injured spinal cord axons
por: Zhu, Zhe, et al.
Publicado: (2016)

Salvianolic Acid A Improves Rat Kidney Injury by Regulating MAPKs and TGF-β1/Smads Signaling Pathways
por: Diao, Hai-Yang, et al.
Publicado: (2023)

The combination of salvianolic acid A with latamoxef completely protects mice against lethal pneumonia caused by methicillin-resistant Staphylococcus aureus
por: Mu, Dan, et al.
Publicado: (2020)

Neuroprotective effect of salvianolate lyophilized injection against cerebral ischemia in type 1 diabetic rats
por: Wang, Fujiang, et al.
Publicado: (2017)

Salvianolic Acid B Attenuates Rat Hepatic Fibrosis via Downregulating Angiotensin II Signaling
por: Li, Shu, et al.
Publicado: (2012)

Pharmacological Effects of Salvianolic Acid B Against Oxidative Damage
por: Xiao, Zhun, et al.
Publicado: (2020)

Smad3 Sensitizes Hepatocelluar Carcinoma Cells to Cisplatin by Repressing Phosphorylation of AKT
por: Zhou, Hong-Hao, et al.
Publicado: (2016)

Salvianolic acid A targeting the transgelin-actin complex to enhance vasoconstriction
por: Zhong, Weilong, et al.
Publicado: (2018)

Salvianolic acid B protects against sepsis-induced liver injury via activation of SIRT1/PGC-1α signaling
por: Su, Hongling, et al.
Publicado: (2020)

Protective efficacy of a single salvianolic acid A treatment on photothrombosis-induced sustained spatial memory impairments
por: Jiao, Chun-Xiang, et al.
Publicado: (2017)

Salvianolic acid B prevents epithelial-to-mesenchymal transition through the TGF-β1 signal transduction pathway in vivo and in vitro
por: Wang, Qing-Lan, et al.
Publicado: (2010)

Mitogen-activated protein kinase inhibitors reduce the nuclear accumulation of phosphorylated Smads by inhibiting Imp 7 or Imp 8 in HepG2 cells
por: Hu, Xiangpeng, et al.
Publicado: (2018)

Salvianolic acid B protects hepatocytes from H(2)O(2) injury by stabilizing the lysosomal membrane
por: Yan, Xiao-Feng, et al.
Publicado: (2017)

Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease
por: Zeng, Wenjing, et al.
Publicado: (2015)

Erythrocyte Membrane-Enveloped Salvianolic Acid B Nanoparticles Attenuate Cerebral Ischemia-Reperfusion Injury
por: Zhang, Shanshan, et al.
Publicado: (2022)

Salvianolic Acid A Protects against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Neutrophil NETosis
por: Liu, Qiang, et al.
Publicado: (2022)

Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region
por: Liu, Xingfeng, et al.
Publicado: (2013)

Protective effects of salvianolic acid B against hydrogen peroxide-induced apoptosis of human umbilical vein endothelial cells and underlying mechanisms
por: Gao, Shan, et al.
Publicado: (2019)

Cardiovascular Effects of Salvianolic Acid B
por: Wang, Jie, et al.
Publicado: (2013)

Inhibition of Tanshinone IIA, Salvianolic Acid A and Salvianolic Acid B on Areca Nut Extract-Induced Oral Submucous Fibrosis in Vitro
por: Dai, Jian-Ping, et al.
Publicado: (2015)

Possible applications of salvianolic acid B against different cancers
por: Shahzadi, Iram, et al.
Publicado: (2020)

Network Pharmacology and Molecular Docking-Based Mechanism Study to Reveal the Protective Effect of Salvianolic Acid C in a Rat Model of Ischemic Stroke
por: Yang, Yuting, et al.
Publicado: (2022)

TGF-Beta Induced Erk Phosphorylation of Smad Linker Region Regulates Smad Signaling
por: Hough, Chris, et al.
Publicado: (2012)

Salvianolic acid B inhibits the progression of liver fibrosis in rats via modulation of the Hedgehog signaling pathway
por: Tao, Shanjun, et al.
Publicado: (2022)

The effectiveness of Salvianolate injection for in-stent restenosis after percutaneous coronary intervention: A protocol for systematic review and meta-analysis
por: Zhang, Miao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_h8ul7p1v9f19ua2vbtk7i2a4gg