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Cardiovascular Effects of Metabolic Surgery on Type 2 Diabetes

INTRODUCTION: Cardiovascular, together with renal disease, claims a significant proportion of morbidity and mortality in association with type 2 diabetes mellitus (T2DM) and obesity. To improve the long-term renal and cardiovascular outcome, there is the incorporation of bariatric surgery (BS), whic...

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Autores principales: Damaskos, Christos, Litos, Alexandros, Dimitroulis, Dimitrios, Antoniou, Efstathios A., Mantas, Dimitrios, Kontzoglou, Konstantinos, Garmpis, Nikolaos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903510/
https://www.ncbi.nlm.nih.gov/pubmed/32077829
http://dx.doi.org/10.2174/1573403X16666200220120226
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author Damaskos, Christos
Litos, Alexandros
Dimitroulis, Dimitrios
Antoniou, Efstathios A.
Mantas, Dimitrios
Kontzoglou, Konstantinos
Garmpis, Nikolaos
author_facet Damaskos, Christos
Litos, Alexandros
Dimitroulis, Dimitrios
Antoniou, Efstathios A.
Mantas, Dimitrios
Kontzoglou, Konstantinos
Garmpis, Nikolaos
author_sort Damaskos, Christos
collection PubMed
description INTRODUCTION: Cardiovascular, together with renal disease, claims a significant proportion of morbidity and mortality in association with type 2 diabetes mellitus (T2DM) and obesity. To improve the long-term renal and cardiovascular outcome, there is the incorporation of bariatric surgery (BS), which seems to be a pivotal intervention. AREAS EXPLORED: Cohort studies and randomized controlled trial (RCT) research of BS among patients with T2DM, were conducted by screening, and then information on renal effects and the cardiovascular outcome was gathered. Metabolic surgery (MS) and BS reduce both mortality and the risk of cardiovascular disorder, chronic kidney diseases and albuminuria. MS refers to a surgical approach, the primary intent of which is the control of metabolic alterations/hyperglycemia in contrast to BS which is a mere weight-reduction therapy. Patients suffering from poor glycaemic control and other macro and micro-vascular diseases will benefit from a surgical approach. The approach implicates hypertension glomerular remission, gut microbiota shift, reduced renal inflammation and fewer instances of chronic cardiac remodelling. CONCLUSION: MS is beneficial where the main aim is to attain significant and long-lasting weight loss results. The RCTs have depicted the superiority which surgical mechanisms hold over medically-based therapy, for enhancing glycaemic control, and achieving remission of diabetes. This type of surgery improves life quality, reduces incidences of other obesity and diabetes related diseases like microvascular disases, sleep apnea, fatal disorder, and fatty liver disease.
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spelling pubmed-79035102021-11-01 Cardiovascular Effects of Metabolic Surgery on Type 2 Diabetes Damaskos, Christos Litos, Alexandros Dimitroulis, Dimitrios Antoniou, Efstathios A. Mantas, Dimitrios Kontzoglou, Konstantinos Garmpis, Nikolaos Curr Cardiol Rev Article INTRODUCTION: Cardiovascular, together with renal disease, claims a significant proportion of morbidity and mortality in association with type 2 diabetes mellitus (T2DM) and obesity. To improve the long-term renal and cardiovascular outcome, there is the incorporation of bariatric surgery (BS), which seems to be a pivotal intervention. AREAS EXPLORED: Cohort studies and randomized controlled trial (RCT) research of BS among patients with T2DM, were conducted by screening, and then information on renal effects and the cardiovascular outcome was gathered. Metabolic surgery (MS) and BS reduce both mortality and the risk of cardiovascular disorder, chronic kidney diseases and albuminuria. MS refers to a surgical approach, the primary intent of which is the control of metabolic alterations/hyperglycemia in contrast to BS which is a mere weight-reduction therapy. Patients suffering from poor glycaemic control and other macro and micro-vascular diseases will benefit from a surgical approach. The approach implicates hypertension glomerular remission, gut microbiota shift, reduced renal inflammation and fewer instances of chronic cardiac remodelling. CONCLUSION: MS is beneficial where the main aim is to attain significant and long-lasting weight loss results. The RCTs have depicted the superiority which surgical mechanisms hold over medically-based therapy, for enhancing glycaemic control, and achieving remission of diabetes. This type of surgery improves life quality, reduces incidences of other obesity and diabetes related diseases like microvascular disases, sleep apnea, fatal disorder, and fatty liver disease. Bentham Science Publishers 2020-11 2020-11 /pmc/articles/PMC7903510/ /pubmed/32077829 http://dx.doi.org/10.2174/1573403X16666200220120226 Text en © 2020 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Damaskos, Christos
Litos, Alexandros
Dimitroulis, Dimitrios
Antoniou, Efstathios A.
Mantas, Dimitrios
Kontzoglou, Konstantinos
Garmpis, Nikolaos
Cardiovascular Effects of Metabolic Surgery on Type 2 Diabetes
title Cardiovascular Effects of Metabolic Surgery on Type 2 Diabetes
title_full Cardiovascular Effects of Metabolic Surgery on Type 2 Diabetes
title_fullStr Cardiovascular Effects of Metabolic Surgery on Type 2 Diabetes
title_full_unstemmed Cardiovascular Effects of Metabolic Surgery on Type 2 Diabetes
title_short Cardiovascular Effects of Metabolic Surgery on Type 2 Diabetes
title_sort cardiovascular effects of metabolic surgery on type 2 diabetes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903510/
https://www.ncbi.nlm.nih.gov/pubmed/32077829
http://dx.doi.org/10.2174/1573403X16666200220120226
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