Cardiovascular and Renal Outcomes of Incretin-based Therapies: A Review of Recent Clinical Trials

BACKGROUND: To report the cardiovascular and renal effects of incretin-based therapies. METHODS: The studies of clinical trials on incretin-based therapy published in medical journals from the years 2010 to 2017 were comprehensively searched using MEDLINE and EMBASE with no language restriction. The...

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Autores principales: Kyriakos, Georgios, Quiles-Sanchez, Lourdes V., Garmpi, Anna, Farmaki, Paraskevi, Kyre, Konstantina, Gkogkos, Spyridon, Savvanis, Spyridon, Memi, Eleni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903512/
https://www.ncbi.nlm.nih.gov/pubmed/31161994
http://dx.doi.org/10.2174/1573403X15666190603111056
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author Kyriakos, Georgios
Quiles-Sanchez, Lourdes V.
Garmpi, Anna
Farmaki, Paraskevi
Kyre, Konstantina
Gkogkos, Spyridon
Savvanis, Spyridon
Memi, Eleni
author_facet Kyriakos, Georgios
Quiles-Sanchez, Lourdes V.
Garmpi, Anna
Farmaki, Paraskevi
Kyre, Konstantina
Gkogkos, Spyridon
Savvanis, Spyridon
Memi, Eleni
author_sort Kyriakos, Georgios
collection PubMed
description BACKGROUND: To report the cardiovascular and renal effects of incretin-based therapies. METHODS: The studies of clinical trials on incretin-based therapy published in medical journals from the years 2010 to 2017 were comprehensively searched using MEDLINE and EMBASE with no language restriction. The studies were reviewed and the cardiovascular and renal risks reported were recorded. RESULTS: Incretin-based therapeutics represent novel and promising anti-diabetes drugs, the direct cardiovascular actions which may translate into demonstrable clinical benefits on cardiovascular outcomes. Furthermore, incretin-based therapies do not adversely affect renal function.
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spelling pubmed-79035122021-11-01 Cardiovascular and Renal Outcomes of Incretin-based Therapies: A Review of Recent Clinical Trials Kyriakos, Georgios Quiles-Sanchez, Lourdes V. Garmpi, Anna Farmaki, Paraskevi Kyre, Konstantina Gkogkos, Spyridon Savvanis, Spyridon Memi, Eleni Curr Cardiol Rev Article BACKGROUND: To report the cardiovascular and renal effects of incretin-based therapies. METHODS: The studies of clinical trials on incretin-based therapy published in medical journals from the years 2010 to 2017 were comprehensively searched using MEDLINE and EMBASE with no language restriction. The studies were reviewed and the cardiovascular and renal risks reported were recorded. RESULTS: Incretin-based therapeutics represent novel and promising anti-diabetes drugs, the direct cardiovascular actions which may translate into demonstrable clinical benefits on cardiovascular outcomes. Furthermore, incretin-based therapies do not adversely affect renal function. Bentham Science Publishers 2020-11 2020-11 /pmc/articles/PMC7903512/ /pubmed/31161994 http://dx.doi.org/10.2174/1573403X15666190603111056 Text en © 2020 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Kyriakos, Georgios
Quiles-Sanchez, Lourdes V.
Garmpi, Anna
Farmaki, Paraskevi
Kyre, Konstantina
Gkogkos, Spyridon
Savvanis, Spyridon
Memi, Eleni
Cardiovascular and Renal Outcomes of Incretin-based Therapies: A Review of Recent Clinical Trials
title Cardiovascular and Renal Outcomes of Incretin-based Therapies: A Review of Recent Clinical Trials
title_full Cardiovascular and Renal Outcomes of Incretin-based Therapies: A Review of Recent Clinical Trials
title_fullStr Cardiovascular and Renal Outcomes of Incretin-based Therapies: A Review of Recent Clinical Trials
title_full_unstemmed Cardiovascular and Renal Outcomes of Incretin-based Therapies: A Review of Recent Clinical Trials
title_short Cardiovascular and Renal Outcomes of Incretin-based Therapies: A Review of Recent Clinical Trials
title_sort cardiovascular and renal outcomes of incretin-based therapies: a review of recent clinical trials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903512/
https://www.ncbi.nlm.nih.gov/pubmed/31161994
http://dx.doi.org/10.2174/1573403X15666190603111056
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