Cargando…

DDX3X: structure, physiologic functions and cancer

The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages of RNA metabolism and participates in the progression of many diseases, including virus infection, inflammation, intellectual disabilities and cancer. Over two decades, many studies have gradually unveiled the role...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mo, Jie, Liang, Huifang, Su, Chen, Li, Pengcheng, Chen, Jin, Zhang, Bixiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903766/ https://www.ncbi.nlm.nih.gov/pubmed/33627125 http://dx.doi.org/10.1186/s12943-021-01325-7

Ejemplares similares

DDX3X and DDX3Y are redundant in protein synthesis
por: Venkataramanan, Srivats, et al.
Publicado: (2021)

DDX3X structural analysis: Implications in the pharmacology and innate immunity
por: De Colibus, Luigi, et al.
Publicado: (2022)

DEAD-Box RNA Helicases DDX3X and DDX5 as Oncogenes or Oncosuppressors: A Network Perspective
por: Secchi, Massimiliano, et al.
Publicado: (2022)

Insight into the structure, physiological function, and role in cancer of m6A readers—YTH domain-containing proteins
por: Liao, Jingyu, et al.
Publicado: (2022)

DEAD-box RNA Helicase DDX3: Functional Properties and Development of DDX3 Inhibitors as Antiviral and Anticancer Drugs
por: Kukhanova, Marina K., et al.
Publicado: (2020)

DDX3, a potential target for cancer treatment
por: Bol, Guus Martinus, et al.
Publicado: (2015)

An azoospermic factor gene, Ddx3y and its paralog, Ddx3x are dispensable in germ cells for male fertility
por: MATSUMURA, Takafumi, et al.
Publicado: (2019)

Prospective and detailed behavioral phenotyping in DDX3X syndrome
por: Tang, Lara, et al.
Publicado: (2021)

DDX3X Multifunctionally Modulates Tumor Progression and Serves as a Prognostic Indicator to Predict Cancer Outcomes
por: Lin, Tsung-Chieh
Publicado: (2019)

DDX3 acts as a tumor suppressor in colorectal cancer as loss of DDX3 in advanced cancer promotes tumor progression by activating the MAPK pathway
por: Shen, Lin, et al.
Publicado: (2022)

Structural and functional analyses of human DDX41 DEAD domain
por: Jiang, Yan, et al.
Publicado: (2016)

Critical roles of FAM134B in ER-phagy and diseases
por: Mo, Jie, et al.
Publicado: (2020)

DDX3X Biomarker Correlates with Poor Survival in Human Gliomas
por: Hueng, Dueng-Yuan, et al.
Publicado: (2015)

Sex Determination of Cattle Meat by Polymerase Chain Reaction Amplification of the DEAD Box Protein (DDX3X/DDX3Y) Gene
por: Gokulakrishnan, P., et al.
Publicado: (2012)

The RNA m(6)A writer WTAP in diseases: structure, roles, and mechanisms
por: Huang, Qibo, et al.
Publicado: (2022)

Erratum to: Structural and functional analyses of human DDX41 DEAD domain
por: Jiang, Yan, et al.
Publicado: (2017)

Functions of DEAD box RNA helicases DDX5 and DDX17 in chromatin organization and transcriptional regulation
por: Giraud, Guillaume, et al.
Publicado: (2018)

DDX20: A Multifunctional Complex Protein
por: He, Lu, et al.
Publicado: (2023)

DDX3X Syndrome Behavioral Manifestations with Particular Emphasis on Psycho-Pathological Symptoms—A Review
por: Stefaniak, Urszula, et al.
Publicado: (2023)

Novel Insights into the Biochemical Mechanism of CK1ε and its Functional Interplay with DDX3X
por: Bono, Bartolo, et al.
Publicado: (2020)

The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity
por: Szappanos, Daniel, et al.
Publicado: (2018)

ALKBH5-mediated m(6)A modification of lincRNA LINC02551 enhances the stability of DDX24 to promote hepatocellular carcinoma growth and metastasis
por: Zhang, Hongwei, et al.
Publicado: (2022)

Phenotypic expansion in DDX3X – a common cause of intellectual disability in females
por: Wang, Xia, et al.
Publicado: (2018)

Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation
por: Valentin-Vega, Yasmine A., et al.
Publicado: (2016)

The role of RNA m(5)C modification in cancer metastasis
por: Zhang, Qiaofeng, et al.
Publicado: (2021)

The Roles of TIF1γ in Cancer
por: Yu, Chengpeng, et al.
Publicado: (2019)

Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X
por: Brai, Annalaura, et al.
Publicado: (2019)

The emerging roles of the DDX41 protein in immunity and diseases
por: Jiang, Yan, et al.
Publicado: (2016)

The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X
por: Song, He, et al.
Publicado: (2019)

The Function, Role and Process of DDX58 in Heart Failure and Human Cancers
por: Yu, Ping, et al.
Publicado: (2022)

DDX3X mRNA Expression in T Cells Is Associated with the Severity and Mortality of Septic Patients
por: Liu, Yukun, et al.
Publicado: (2022)

Interaction of SARS-CoV-2 Nucleocapsid Protein and Human RNA Helicases DDX1 and DDX3X Modulates Their Activities on Double-Stranded RNA
por: Lodola, Camilla, et al.
Publicado: (2023)

PinX1: structure, regulation and its functions in cancer
por: Li, Hai-Long, et al.
Publicado: (2016)

The translational landscape as regulated by the RNA helicase DDX3
por: Park, Joon Tae, et al.
Publicado: (2022)

Cytoplasmic DDX3 as prognosticator in male breast cancer
por: van der Pol, Carmen C., et al.
Publicado: (2021)

Venezuelan equine encephalitis virus non-structural protein 3 (nsP3) interacts with RNA helicases DDX1 and DDX3 in infected cells
por: Amaya, Moushimi, et al.
Publicado: (2016)

Dengue Virus Capsid Interacts with DDX3X–A Potential Mechanism for Suppression of Antiviral Functions in Dengue Infection
por: Kumar, Rinki, et al.
Publicado: (2018)

DDX3X promotes the biogenesis of a subset of miRNAs and the potential roles they played in cancer development
por: Zhao, Luqing, et al.
Publicado: (2016)

DEPTOR induces a partial epithelial-to-mesenchymal transition and metastasis via autocrine TGFβ1 signaling and is associated with poor prognosis in hepatocellular carcinoma
por: Chen, Jin, et al.
Publicado: (2019)

KLHL29-mediated DDX3X degradation promotes chemosensitivity by abrogating cell cycle checkpoint in triple-negative breast cancer
por: Yao, Litong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ujvcfgiehio67d1rmjlj7hb7ut