Cargando…

DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination

BACKGROUND: DNA primase subunit 1 (PRIM1) has been reported as a novel oncogene in several cancer types. However, its roles in hepatocellular carcinoma (HCC) remain unclear. This study aimed to investigate underlying mechanisms of PRIM1 and identify it as a potential molecular target for HCC. METHOD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Mengqi, Wu, Mengna, Bian, Saiyan, Song, Qianqian, Xiao, Mingbing, Huang, Hua, You, Li, Zhang, Jianping, Zhang, Jie, Cheng, Chun, Ni, Wenkai, Zheng, Wenjie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903777/ https://www.ncbi.nlm.nih.gov/pubmed/33622397 http://dx.doi.org/10.1186/s13578-021-00555-y

Ejemplares similares

Identification and Validation of Ubiquitin-Specific Proteases as a Novel Prognostic Signature for Hepatocellular Carcinoma
por: Ni, Wenkai, et al.
Publicado: (2021)

Flap endonuclease 1 Facilitated Hepatocellular Carcinoma Progression by Enhancing USP7/MDM2-mediated P53 Inactivation
por: Bian, Saiyan, et al.
Publicado: (2022)

Identification and Validation of the N6-Methyladenosine RNA Methylation Regulator YTHDF1 as a Novel Prognostic Marker and Potential Target for Hepatocellular Carcinoma
por: Bian, Saiyan, et al.
Publicado: (2020)

Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance
por: Zhang, Wei, et al.
Publicado: (2020)

Control of mTOR Signaling by Ubiquitin
por: Jiang, Yao, et al.
Publicado: (2019)

USP7 mediates pathological hepatic de novo lipogenesis through promoting stabilization and transcription of ZNF638
por: Ni, Wenkai, et al.
Publicado: (2020)

Biological testing of chitosan‐collagen‐based porous scaffolds loaded with PLGA/Triamcinolone microspheres for ameliorating endoscopic dissection‐related stenosis in oesophagus
por: Ni, Wenkai, et al.
Publicado: (2021)

Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development
por: Kong, Xiangxing, et al.
Publicado: (2022)

UBE2T promotes autophagy via the p53/AMPK/mTOR signaling pathway in lung adenocarcinoma
por: Zhu, Jinhong, et al.
Publicado: (2021)

UBE2C Drives Human Cervical Cancer Progression and Is Positively Modulated by mTOR
por: Chiang, An-Jen, et al.
Publicado: (2020)

DNA Primase Subunit 1 Expression in Hepatocellular Carcinoma and Its Clinical Implication
por: Zhang, Yipeng, et al.
Publicado: (2020)

UBE2C affects breast cancer proliferation through the AKT/mTOR signaling pathway
por: Lu, Zi-Nan, et al.
Publicado: (2021)

The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells
por: Shapira, Ma'anit, et al.
Publicado: (2006)

Circadian gene CSNK1D promoted the progression of hepatocellular carcinoma by activating Wnt/β-catenin pathway via stabilizing Dishevelled Segment Polarity Protein 3
por: Zhu, Mengqi, et al.
Publicado: (2022)

Correction to: The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells
por: Shapira, Ma’anit, et al.
Publicado: (2018)

Shared Active Site Architecture between the Large Subunit of Eukaryotic Primase and DNA Photolyase
por: Sauguet, Ludovic, et al.
Publicado: (2010)

Crystal Structure of a Ube2S-Ubiquitin Conjugate
por: Lorenz, Sonja, et al.
Publicado: (2016)

Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile
por: van Eijk, Erika, et al.
Publicado: (2016)

UBE2O promotes hepatocellular carcinoma cell proliferation and invasion by regulating the AMPKα2/mTOR pathway
por: Shi, Zhan, et al.
Publicado: (2021)

UBE2S promotes the development of ovarian cancer by promoting PI3K/AKT/mTOR signaling pathway to regulate cell cycle and apoptosis
por: Zhang, Mengjun, et al.
Publicado: (2022)

Molecular Dissection of the Primase and Polymerase Activities of Deep-Sea Phage NrS-1 Primase-Polymerase
por: Huang, Fengtao, et al.
Publicado: (2021)

Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells
por: Li, Xiaoli, et al.
Publicado: (2018)

Non-Thermal Plasma Induces Antileukemic Effect Through mTOR Ubiquitination
por: Kim, Sun-Yong, et al.
Publicado: (2020)

Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma
por: Zhang, Jie, et al.
Publicado: (2020)

The archaeo-eukaryotic GINS proteins and the archaeal primase catalytic subunit PriS share a common domain
por: Swiatek, Agnieszka, et al.
Publicado: (2010)

Corrigendum: Molecular Dissection of the Primase and Polymerase Activities of Deep-Sea Phage NrS-1 Primase-Polymerase
por: Huang, Fengtao, et al.
Publicado: (2022)

Decision-making by p53 and mTOR
por: Maki, Carl G.
Publicado: (2010)

Linalool Impress Colorectal Cancer Deterioration by Mediating AKT/mTOR and JAK2/STAT3 Signaling Pathways
por: Hou, Min, et al.
Publicado: (2022)

Intrinsic disorder drives N-terminal ubiquitination by Ube2w
por: Vittal, Vinayak, et al.
Publicado: (2014)

Detailed Dissection of UBE3A-Mediated DDI1 Ubiquitination
por: Elu, Nagore, et al.
Publicado: (2019)

Primase-based whole genome amplification
por: Li, Ying, et al.
Publicado: (2008)

Residues located in the primase domain of the bacteriophage T7 primase-helicase are essential for loading the hexameric complex onto DNA
por: Hernandez, Alfredo J., et al.
Publicado: (2022)

The monomeric archaeal primase from Nanoarchaeum equitans harbours the features of heterodimeric archaeoeukaryotic primases and primes sequence-specifically
por: Schneider, Andy, et al.
Publicado: (2023)

DNA primase large subunit is an essential plant gene for geminiviruses, putatively priming viral ss-DNA replication
por: Siskos, Lampros, et al.
Publicado: (2023)

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
por: Tian, Tian, et al.
Publicado: (2019)

UBE2T promotes glioblastoma malignancy through ubiquitination‐mediated degradation of RPL6
por: Tao, Xuxiu, et al.
Publicado: (2022)

The lncRNA B3GALT5-AS1 Functions as an HCC Suppressor by Regulating the miR-934/UFM1 Axis
por: Chen, Erlin, et al.
Publicado: (2021)

The molecular basis of lysine 48 ubiquitin chain synthesis by Ube2K
por: Middleton, Adam J., et al.
Publicado: (2015)

Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W
por: Davies, Christopher W., et al.
Publicado: (2021)

Conjugation of the Ubiquitin Activating Enzyme UBE1 with the Ubiquitin-Like Modifier FAT10 Targets It for Proteasomal Degradation
por: Bialas, Johanna, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_clcrplrc9kcm3rqt60vlaaonmg