Deadly COVID-19 among the elderly: Innate immune memory helping those most in need

Age is a key risk factor associated with the severity of symptoms caused by SARS-CoV-2, and there is an urgent need to reduce COVID-19 morbidity and mortality in elderly individuals. We discuss evidence suggesting that trained immunity elicited by BCG vaccination may improve immune responses and can...

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Autores principales: Sohrabi, Yahya, Reinecke, Holger, Joosten, Leo A.B., Netea, Mihai G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903897/
https://www.ncbi.nlm.nih.gov/pubmed/33649749
http://dx.doi.org/10.1016/j.medj.2021.02.004
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author Sohrabi, Yahya
Reinecke, Holger
Joosten, Leo A.B.
Netea, Mihai G.
author_facet Sohrabi, Yahya
Reinecke, Holger
Joosten, Leo A.B.
Netea, Mihai G.
author_sort Sohrabi, Yahya
collection PubMed
description Age is a key risk factor associated with the severity of symptoms caused by SARS-CoV-2, and there is an urgent need to reduce COVID-19 morbidity and mortality in elderly individuals. We discuss evidence suggesting that trained immunity elicited by BCG vaccination may improve immune responses and can serve as a strategy to combat COVID-19 in this population.
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spelling pubmed-79038972021-02-25 Deadly COVID-19 among the elderly: Innate immune memory helping those most in need Sohrabi, Yahya Reinecke, Holger Joosten, Leo A.B. Netea, Mihai G. Med (N Y) Commentary Age is a key risk factor associated with the severity of symptoms caused by SARS-CoV-2, and there is an urgent need to reduce COVID-19 morbidity and mortality in elderly individuals. We discuss evidence suggesting that trained immunity elicited by BCG vaccination may improve immune responses and can serve as a strategy to combat COVID-19 in this population. Elsevier Inc. 2021-04-09 2021-02-24 /pmc/articles/PMC7903897/ /pubmed/33649749 http://dx.doi.org/10.1016/j.medj.2021.02.004 Text en © 2021 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Commentary
Sohrabi, Yahya
Reinecke, Holger
Joosten, Leo A.B.
Netea, Mihai G.
Deadly COVID-19 among the elderly: Innate immune memory helping those most in need
title Deadly COVID-19 among the elderly: Innate immune memory helping those most in need
title_full Deadly COVID-19 among the elderly: Innate immune memory helping those most in need
title_fullStr Deadly COVID-19 among the elderly: Innate immune memory helping those most in need
title_full_unstemmed Deadly COVID-19 among the elderly: Innate immune memory helping those most in need
title_short Deadly COVID-19 among the elderly: Innate immune memory helping those most in need
title_sort deadly covid-19 among the elderly: innate immune memory helping those most in need
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903897/
https://www.ncbi.nlm.nih.gov/pubmed/33649749
http://dx.doi.org/10.1016/j.medj.2021.02.004
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