Cargando…

The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway

Metabolism-mediated epigenetic changes represent an adapted mechanism for cellular signaling, in which lysine acetylation and methylation have been the historical focus of interest. We recently discovered a β-hydroxybutyrate–mediated epigenetic pathway that couples metabolism to gene expression. How...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, He, Zhang, Di, Weng, Yejing, Delaney, Kyle, Tang, Zhanyun, Yan, Cong, Qi, Shankang, Peng, Chao, Cole, Philip A., Roeder, Robert G., Zhao, Yingming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904266/ https://www.ncbi.nlm.nih.gov/pubmed/33627428 http://dx.doi.org/10.1126/sciadv.abe2771

Ejemplares similares

Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation
por: Koronowski, Kevin B., et al.
Publicado: (2021)

Proteome-wide analysis of lysine β-hydroxybutyrylation in the myocardium of diabetic rat model with cardiomyopathy
por: Luo, Weiguang, et al.
Publicado: (2023)

p53 β-hydroxybutyrylation attenuates p53 activity
por: Liu, Kun, et al.
Publicado: (2019)

Quantitative Proteomics Analysis Expands the Roles of Lysine β-Hydroxybutyrylation Pathway in Response to Environmental β-Hydroxybutyrate
por: Hou, Wanting, et al.
Publicado: (2022)

Function and mechanism of histone β-hydroxybutyrylation in health and disease
por: Zhou, Tingting, et al.
Publicado: (2022)

Molecular basis for hierarchical histone de-β-hydroxybutyrylation by SIRT3
por: Zhang, Xingrun, et al.
Publicado: (2019)

Post-Translational Modification β-Hydroxybutyrylation Regulates Ustilaginoidea virens Virulence
por: Chen, Xiaoyang, et al.
Publicado: (2023)

Proteomics and β-hydroxybutyrylation Modification Characterization in the Hearts of Naturally Senescent Mice
por: Yang, Xuechun, et al.
Publicado: (2023)

Quantification and Proteomic Characterization of β-Hydroxybutyrylation Modification in the Hearts of AMPKα2 Knockout Mice
por: Ding, Wen-jing, et al.
Publicado: (2023)

The regulation of Tfh cell differentiation by β-hydroxybutyrylation modification of transcription factor Bcl6
por: Guo, Jingtian, et al.
Publicado: (2023)

HBO1 catalyzes lysine benzoylation in mammalian cells
por: Tan, Doudou, et al.
Publicado: (2022)

An optimized method using peptide arrays for the identification of in vitro substrates of lysine methyltransferase enzymes
por: Rowe, Elyn M., et al.
Publicado: (2018)

Metformin promotes female germline stem cell proliferation by upregulating Gata-binding protein 2 with histone β-hydroxybutyrylation
por: Wang, Xiang, et al.
Publicado: (2023)

Quantitative Proteomics Reveals the Role of Lysine 2-Hydroxyisobutyrylation Pathway Mediated by Tip60
por: Wang, Ning, et al.
Publicado: (2022)

Acetogenic production of 3-Hydroxybutyrate using a native 3-Hydroxybutyryl-CoA Dehydrogenase
por: Lo, Jonathan, et al.
Publicado: (2022)

MTA2 triggered R-loop trans-regulates BDH1-mediated β-hydroxybutyrylation and potentiates propagation of hepatocellular carcinoma stem cells
por: Zhang, Heng, et al.
Publicado: (2021)

Lysine Fatty Acylation: Regulatory Enzymes, Research Tools, and Biological Function
por: Komaniecki, Garrison, et al.
Publicado: (2021)

Neurocognitive assessments and long-term outcome in an adult with 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency
por: Stepien, Karolina M., et al.
Publicado: (2018)

(S)-3-Hydroxybutyryl-CoA Dehydrogenase From the Autotrophic 3-Hydroxypropionate/4-Hydroxybutyrate Cycle in Nitrosopumilus maritimus
por: Liu, Li, et al.
Publicado: (2021)

Evaluation of Jumonji C lysine demethylase substrate preference to guide identification of in vitro substrates
por: Hoekstra, Matthew, et al.
Publicado: (2022)

Structural insights into Parkin substrate lysine targeting from minimal Miro substrates
por: Klosowiak, Julian L., et al.
Publicado: (2016)

The Chlamydomonas cell wall degrading enzyme, lysin, acts on two substrates within the framework of the wall
Publicado: (1988)

Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury
por: Cornille, Emilie, et al.
Publicado: (2010)

Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters
por: Goudarzi, Afsaneh, et al.
Publicado: (2016)

The enzyme activity of mitochondrial trifunctional protein is not altered by lysine acetylation or lysine succinylation
por: Zhang, Yuxun, et al.
Publicado: (2021)

Characterization and identification of lysine glutarylation based on intrinsic interdependence between positions in the substrate sites
por: Huang, Kai-Yao, et al.
Publicado: (2019)

Combining free energy calculations with tailored enzyme activity assays to elucidate substrate binding of a phospho-lysine phosphatase
por: Hauser, Anett, et al.
Publicado: (2020)

A Chemical Method for Labeling Lysine Methyltransferase Substrates
por: Binda, Olivier, et al.
Publicado: (2011)

Identification of lysine-lactylated substrates in gastric cancer cells
por: Yang, Dawei, et al.
Publicado: (2022)

Identification of nonhistone substrates of the lysine methyltransferase PRDM9
por: Hanquier, Jocelyne N., et al.
Publicado: (2023)

Metabolic regulation of gene expression by histone lactylation
por: Zhang, Di, et al.
Publicado: (2019)

The Target of the NSD Family of Histone Lysine Methyltransferases Depends on the Nature of the Substrate
por: Li, Yan, et al.
Publicado: (2009)

Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2
por: Delaney, Kyle, et al.
Publicado: (2021)

Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8
por: Ma, Anqi, et al.
Publicado: (2014)

Bioinformatic Analysis and Post-Translational Modification Crosstalk Prediction of Lysine Acetylation
por: Lu, Zhike, et al.
Publicado: (2011)

Protein Lysine Acetylation by p300/CBP
por: Dancy, Beverley M., et al.
Publicado: (2015)

A proteomic approach for the identification of novel lysine methyltransferase substrates
por: Levy, Dan, et al.
Publicado: (2011)

Substrate Scope for Human Histone Lysine Acetyltransferase KAT8
por: Proietti, Giordano, et al.
Publicado: (2021)

Design of Peptide Substrate for Sensitively and Specifically Detecting Two Aβ-Degrading Enzymes: Neprilysin and Angiotensin-Converting Enzyme
por: Chen, Po-Ting, et al.
Publicado: (2016)

Correction to Protein Lysine Acetylation by p300/CBP
por: Dancy, Beverley M., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_n3i03q15fgatkjm0c3qvqf8abc