Targeting a Helix-in-Groove Interaction Between E1 and E2 Blocks Ubiquitin Transfer

The ubiquitin-proteasome system (UPS) is a highly-regulated protein disposal process critical to cell survival. Inhibiting the pathway induces proteotoxic stress and can be effective cancer treatment. The therapeutic window observed upon proteosomal blockade has motivated multiple UPS-targeting stra...

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Detalles Bibliográficos
Autores principales: Cathcart, Ann M., Bird, Gregory H., Wales, Thomas E., Herce, Henry D., Harvey, Edward P., Hauseman, Zachary J., Newman, Catherine E., Adhikary, Utsarga, Prew, Michelle S., Oo, Tun, Lee, Susan, Engen, John R., Walensky, Loren D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904387/
https://www.ncbi.nlm.nih.gov/pubmed/32807965
http://dx.doi.org/10.1038/s41589-020-0625-7

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