Cargando…

COVID-19 vaccination in patients with diabetes mellitus: Current concepts, uncertainties and challenges

BACKGROUND AND AIMS: To summarize the available evidence on the use COVID-19 vaccines in patients with diabetes mellitus. METHODS: We performed a thorough literature search with regard to COVID-19 vaccines in patients with type 1 and type 2 diabetes mellitus. RESULTS: The novel coronavirus disease (...

Descripción completa

Detalles Bibliográficos
Autores principales: Pal, Rimesh, Bhadada, Sanjay Kumar, Misra, Anoop
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Diabetes India. Published by Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904463/
https://www.ncbi.nlm.nih.gov/pubmed/33662837
http://dx.doi.org/10.1016/j.dsx.2021.02.026
_version_ 1783654935256104960
author Pal, Rimesh
Bhadada, Sanjay Kumar
Misra, Anoop
author_facet Pal, Rimesh
Bhadada, Sanjay Kumar
Misra, Anoop
author_sort Pal, Rimesh
collection PubMed
description BACKGROUND AND AIMS: To summarize the available evidence on the use COVID-19 vaccines in patients with diabetes mellitus. METHODS: We performed a thorough literature search with regard to COVID-19 vaccines in patients with type 1 and type 2 diabetes mellitus. RESULTS: The novel coronavirus disease (COVID-19) tends to portend a poor prognosis in patients with diabetes mellitus (DM). Primary prevention remains the mainstay for mitigating the risks associated with COVID-19 in patients with DM. A significant step in primary prevention is timely vaccination. Routine vaccination against pneumococcal pneumonia, influenza, and hepatitis B is recommended in patients with DM with good efficacy and reasonable safety profile. With clinical data supporting a robust neutralizing antibody response in COVID-19 patients with DM, vaccination in individuals with DM is justified. In fact, as the burden of the disease is borne by people with DM, COVID-19 vaccination should be prioritized in individuals with DM. Multiple unresolved issues with regard to preferred vaccine type, vaccine efficacy and durability, frequency of administration, vaccination in children (<18 years) and pregnant/lactating women however remain, and need to be addressed through future research. CONCLUSIONS: Patients with type 1 and type 2 diabetes mellitus are at a high risk of poor prognosis with COVID-19 and vaccination should be prioritized in them. However, many unresolved issues with regard to COVID-19 vaccination need to be addressed through future research.
format Online
Article
Text
id pubmed-7904463
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Diabetes India. Published by Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-79044632021-02-25 COVID-19 vaccination in patients with diabetes mellitus: Current concepts, uncertainties and challenges Pal, Rimesh Bhadada, Sanjay Kumar Misra, Anoop Diabetes Metab Syndr Article BACKGROUND AND AIMS: To summarize the available evidence on the use COVID-19 vaccines in patients with diabetes mellitus. METHODS: We performed a thorough literature search with regard to COVID-19 vaccines in patients with type 1 and type 2 diabetes mellitus. RESULTS: The novel coronavirus disease (COVID-19) tends to portend a poor prognosis in patients with diabetes mellitus (DM). Primary prevention remains the mainstay for mitigating the risks associated with COVID-19 in patients with DM. A significant step in primary prevention is timely vaccination. Routine vaccination against pneumococcal pneumonia, influenza, and hepatitis B is recommended in patients with DM with good efficacy and reasonable safety profile. With clinical data supporting a robust neutralizing antibody response in COVID-19 patients with DM, vaccination in individuals with DM is justified. In fact, as the burden of the disease is borne by people with DM, COVID-19 vaccination should be prioritized in individuals with DM. Multiple unresolved issues with regard to preferred vaccine type, vaccine efficacy and durability, frequency of administration, vaccination in children (<18 years) and pregnant/lactating women however remain, and need to be addressed through future research. CONCLUSIONS: Patients with type 1 and type 2 diabetes mellitus are at a high risk of poor prognosis with COVID-19 and vaccination should be prioritized in them. However, many unresolved issues with regard to COVID-19 vaccination need to be addressed through future research. Diabetes India. Published by Elsevier Ltd. 2021 2021-02-25 /pmc/articles/PMC7904463/ /pubmed/33662837 http://dx.doi.org/10.1016/j.dsx.2021.02.026 Text en © 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Pal, Rimesh
Bhadada, Sanjay Kumar
Misra, Anoop
COVID-19 vaccination in patients with diabetes mellitus: Current concepts, uncertainties and challenges
title COVID-19 vaccination in patients with diabetes mellitus: Current concepts, uncertainties and challenges
title_full COVID-19 vaccination in patients with diabetes mellitus: Current concepts, uncertainties and challenges
title_fullStr COVID-19 vaccination in patients with diabetes mellitus: Current concepts, uncertainties and challenges
title_full_unstemmed COVID-19 vaccination in patients with diabetes mellitus: Current concepts, uncertainties and challenges
title_short COVID-19 vaccination in patients with diabetes mellitus: Current concepts, uncertainties and challenges
title_sort covid-19 vaccination in patients with diabetes mellitus: current concepts, uncertainties and challenges
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904463/
https://www.ncbi.nlm.nih.gov/pubmed/33662837
http://dx.doi.org/10.1016/j.dsx.2021.02.026
work_keys_str_mv AT palrimesh covid19vaccinationinpatientswithdiabetesmellituscurrentconceptsuncertaintiesandchallenges
AT bhadadasanjaykumar covid19vaccinationinpatientswithdiabetesmellituscurrentconceptsuncertaintiesandchallenges
AT misraanoop covid19vaccinationinpatientswithdiabetesmellituscurrentconceptsuncertaintiesandchallenges