Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly

E3 ligases are typically classified by hallmark domains such as RING and RBR, which are thought to specify unique catalytic mechanisms of ubiquitin transfer to recruited substrates(1,2). However, rather than functioning individually, many neddylated cullin–RING E3 ligases (CRLs) and RBR-type E3 liga...

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Detalles Bibliográficos
Autores principales: Horn-Ghetko, Daniel, Krist, David T., Prabu, J. Rajan, Baek, Kheewoong, Mulder, Monique P. C., Klügel, Maren, Scott, Daniel C., Ovaa, Huib, Kleiger, Gary, Schulman, Brenda A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904520/
https://www.ncbi.nlm.nih.gov/pubmed/33536622
http://dx.doi.org/10.1038/s41586-021-03197-9

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