The enzyme subunit SubA of Shiga toxin-producing E. coli strains demonstrates comparable intracellular transport and cytotoxic activity as the holotoxin SubAB in HeLa and HCT116 cells in vitro

The subtilase cytotoxin (SubAB) is secreted by certain Shiga toxin-producing Escherichia coli (STEC) strains and is composed of the enzymatically active subunit SubA and the pentameric binding/transport subunit SubB. We previously demonstrated that SubA (10 µg/ml), in the absence of SubB, binds and...

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Detalles Bibliográficos
Autores principales: Sessler, Katharina, Papatheodorou, Panagiotis, Wondany, Fanny, Krause, Maike, Noettger, Sabrina, Bernhard, Denise, Michaelis, Jens, Schmidt, Herbert, Barth, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Molecular Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904543/
https://www.ncbi.nlm.nih.gov/pubmed/33483759
http://dx.doi.org/10.1007/s00204-020-02965-2

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