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Cytochrome P450 expression, induction and activity in human induced pluripotent stem cell-derived intestinal organoids and comparison with primary human intestinal epithelial cells and Caco-2 cells

Human intestinal organoids (HIOs) are a promising in vitro model consisting of different intestinal cell types with a 3D microarchitecture resembling native tissue. In the current study, we aimed to assess the expression of the most common intestinal CYP enzymes in a human induced pluripotent stem c...

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Detalles Bibliográficos
Autores principales:	Janssen, Aafke W. F., Duivenvoorde, Loes P. M., Rijkers, Deborah, Nijssen, Rosalie, Peijnenburg, Ad A. C. M., van der Zande, Meike, Louisse, Jochem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Toxicokinetics and Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904554/ https://www.ncbi.nlm.nih.gov/pubmed/33263786 http://dx.doi.org/10.1007/s00204-020-02953-6

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