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Mild Motor Signs Matter in Typical Brain Aging: The Value of the UPDRS Score Within a Functionally Intact Cohort of Older Adults

Objectives: To characterize the clinical correlates of subclinical Parkinsonian signs, including longitudinal cognitive and neural (via functional connectivity) outcomes, among functionally normal older adults. Methods: Participants included 737 functionally intact community-dwelling older adults wh...

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Autores principales: Zitser, Jennifer, Casaletto, Kaitlin B., Staffaroni, Adam M., Sexton, Claire, Weiner-Light, Sophia, Wolf, Amy, Brown, Jesse A., Miller, Bruce L., Kramer, Joel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904682/
https://www.ncbi.nlm.nih.gov/pubmed/33643020
http://dx.doi.org/10.3389/fnagi.2021.594637
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author Zitser, Jennifer
Casaletto, Kaitlin B.
Staffaroni, Adam M.
Sexton, Claire
Weiner-Light, Sophia
Wolf, Amy
Brown, Jesse A.
Miller, Bruce L.
Kramer, Joel H.
author_facet Zitser, Jennifer
Casaletto, Kaitlin B.
Staffaroni, Adam M.
Sexton, Claire
Weiner-Light, Sophia
Wolf, Amy
Brown, Jesse A.
Miller, Bruce L.
Kramer, Joel H.
author_sort Zitser, Jennifer
collection PubMed
description Objectives: To characterize the clinical correlates of subclinical Parkinsonian signs, including longitudinal cognitive and neural (via functional connectivity) outcomes, among functionally normal older adults. Methods: Participants included 737 functionally intact community-dwelling older adults who performed prospective comprehensive evaluations at ~15-months intervals for an average of 4.8 years (standard deviation 3.2 years). As part of these evaluations, participants completed the Unified Parkinson's Disease Rating Scale (UPDRS) longitudinally and measures of processing speed, executive functioning and verbal episodic memory. T1-weighted structural scans and task-free functional MRI scans were acquired on 330 participants. We conducted linear mixed-effects models to determine the relationship between changes in UPDRS with cognitive and neural changes, using age, sex, and education as covariates. Results: Cognitive outcomes were processing speed, executive functioning, and episodic memory. Greater within-person increases in UPDRS were associated with more cognitive slowing over time. Although higher average UPDRS scores were significantly associated with overall poorer executive functions, there was no association between UPDRS and executive functioning longitudinally. UPDRS scores did not significantly relate to longitudinal memory performances. Regarding neural correlates, greater increases in UPDRS scores were associated with reduced intra-subcortical network connectivity over time. There were no relationships with intra-frontoparietal or inter-subcortical-frontoparietal connectivity. Conclusions: Our findings add to the aging literature by indicating that mild motor changes are negatively associated with cognition and network connectivity in functionally intact adults.
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spelling pubmed-79046822021-02-26 Mild Motor Signs Matter in Typical Brain Aging: The Value of the UPDRS Score Within a Functionally Intact Cohort of Older Adults Zitser, Jennifer Casaletto, Kaitlin B. Staffaroni, Adam M. Sexton, Claire Weiner-Light, Sophia Wolf, Amy Brown, Jesse A. Miller, Bruce L. Kramer, Joel H. Front Aging Neurosci Neuroscience Objectives: To characterize the clinical correlates of subclinical Parkinsonian signs, including longitudinal cognitive and neural (via functional connectivity) outcomes, among functionally normal older adults. Methods: Participants included 737 functionally intact community-dwelling older adults who performed prospective comprehensive evaluations at ~15-months intervals for an average of 4.8 years (standard deviation 3.2 years). As part of these evaluations, participants completed the Unified Parkinson's Disease Rating Scale (UPDRS) longitudinally and measures of processing speed, executive functioning and verbal episodic memory. T1-weighted structural scans and task-free functional MRI scans were acquired on 330 participants. We conducted linear mixed-effects models to determine the relationship between changes in UPDRS with cognitive and neural changes, using age, sex, and education as covariates. Results: Cognitive outcomes were processing speed, executive functioning, and episodic memory. Greater within-person increases in UPDRS were associated with more cognitive slowing over time. Although higher average UPDRS scores were significantly associated with overall poorer executive functions, there was no association between UPDRS and executive functioning longitudinally. UPDRS scores did not significantly relate to longitudinal memory performances. Regarding neural correlates, greater increases in UPDRS scores were associated with reduced intra-subcortical network connectivity over time. There were no relationships with intra-frontoparietal or inter-subcortical-frontoparietal connectivity. Conclusions: Our findings add to the aging literature by indicating that mild motor changes are negatively associated with cognition and network connectivity in functionally intact adults. Frontiers Media S.A. 2021-02-11 /pmc/articles/PMC7904682/ /pubmed/33643020 http://dx.doi.org/10.3389/fnagi.2021.594637 Text en Copyright © 2021 Zitser, Casaletto, Staffaroni, Sexton, Weiner-Light, Wolf, Brown, Miller and Kramer. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zitser, Jennifer
Casaletto, Kaitlin B.
Staffaroni, Adam M.
Sexton, Claire
Weiner-Light, Sophia
Wolf, Amy
Brown, Jesse A.
Miller, Bruce L.
Kramer, Joel H.
Mild Motor Signs Matter in Typical Brain Aging: The Value of the UPDRS Score Within a Functionally Intact Cohort of Older Adults
title Mild Motor Signs Matter in Typical Brain Aging: The Value of the UPDRS Score Within a Functionally Intact Cohort of Older Adults
title_full Mild Motor Signs Matter in Typical Brain Aging: The Value of the UPDRS Score Within a Functionally Intact Cohort of Older Adults
title_fullStr Mild Motor Signs Matter in Typical Brain Aging: The Value of the UPDRS Score Within a Functionally Intact Cohort of Older Adults
title_full_unstemmed Mild Motor Signs Matter in Typical Brain Aging: The Value of the UPDRS Score Within a Functionally Intact Cohort of Older Adults
title_short Mild Motor Signs Matter in Typical Brain Aging: The Value of the UPDRS Score Within a Functionally Intact Cohort of Older Adults
title_sort mild motor signs matter in typical brain aging: the value of the updrs score within a functionally intact cohort of older adults
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904682/
https://www.ncbi.nlm.nih.gov/pubmed/33643020
http://dx.doi.org/10.3389/fnagi.2021.594637
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