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The 28 + 28 day design is an effective sampling time for analyzing mutant frequencies in rapidly proliferating tissues of MutaMouse animals

The Organisation for Economic Co-Operation and Development Test Guideline 488 (TG 488) uses transgenic rodent models to generate in vivo mutagenesis data for regulatory submission. The recommended design in TG 488, 28 consecutive daily exposures with tissue sampling three days later (28 + 3d), is op...

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Detalles Bibliográficos
Autores principales:	Marchetti, Francesco, Zhou, Gu, LeBlanc, Danielle, White, Paul A., Williams, Andrew, Yauk, Carole L., Douglas, George R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Genotoxicity and Carcinogenicity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904718/ https://www.ncbi.nlm.nih.gov/pubmed/33506374 http://dx.doi.org/10.1007/s00204-021-02977-6

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