Identification of potential novel drug resistance mechanisms by genomic and transcriptomic profiling of colon cancer cells with p53 deletion

TP53 (p53) is a pivotal player in tumor suppression with fifty percent of all invasive tumors displaying mutations in the TP53 gene. In the present study, we characterized colon cancer cells (HCT116 p53 (−/−)) with TP53 deletion, a sub-line derived from HCT116-p53 (+/+) cells. RNA sequencing and net...

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Detalles Bibliográficos
Autores principales: Kadioglu, Onat, Saeed, Mohamed, Mahmoud, Nuha, Azawi, Shaymaa, Mrasek, Kristin, Liehr, Thomas, Efferth, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Molecular Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904745/
https://www.ncbi.nlm.nih.gov/pubmed/33515271
http://dx.doi.org/10.1007/s00204-021-02979-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904745/
https://www.ncbi.nlm.nih.gov/pubmed/33515271
http://dx.doi.org/10.1007/s00204-021-02979-4

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