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Identification of potential novel drug resistance mechanisms by genomic and transcriptomic profiling of colon cancer cells with p53 deletion
TP53 (p53) is a pivotal player in tumor suppression with fifty percent of all invasive tumors displaying mutations in the TP53 gene. In the present study, we characterized colon cancer cells (HCT116 p53 (−/−)) with TP53 deletion, a sub-line derived from HCT116-p53 (+/+) cells. RNA sequencing and net...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904745/ https://www.ncbi.nlm.nih.gov/pubmed/33515271 http://dx.doi.org/10.1007/s00204-021-02979-4 |