The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation

The host defence peptide cathelicidin (LL-37 in humans, mCRAMP in mice) is released from neutrophils by de-granulation, NETosis and necrotic death; it has potent anti-pathogen activity as well as being a broad immunomodulator. Here we report that cathelicidin is a powerful Th17 potentiator which enh...

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Detalles Bibliográficos
Autores principales: Minns, Danielle, Smith, Katie J., Alessandrini, Virginia, Hardisty, Gareth, Melrose, Lauren, Jackson-Jones, Lucy, MacDonald, Andrew S., Davidson, Donald J., Gwyer Findlay, Emily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904761/
https://www.ncbi.nlm.nih.gov/pubmed/33627652
http://dx.doi.org/10.1038/s41467-021-21533-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904761/
https://www.ncbi.nlm.nih.gov/pubmed/33627652
http://dx.doi.org/10.1038/s41467-021-21533-5

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