Cargando…

Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged Wild-type mice

Brain aging is a natural process characterized by cognitive decline and memory loss. This impairment is related to mitochondrial dysfunction and has recently been linked to the accumulation of abnormal proteins in the hippocampus. Age-related mitochondrial dysfunction could be induced by modified fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Torres, Angie K., Jara, Claudia, Olesen, Margrethe A., Tapia-Rojas, Cheril
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904815/ https://www.ncbi.nlm.nih.gov/pubmed/33627790 http://dx.doi.org/10.1038/s41598-021-83910-w

Ejemplares similares

Phosphorylated tau as a toxic agent in synaptic mitochondria: implications in aging and Alzheimer’s disease
por: Torres, Angie K., et al.
Publicado: (2022)

Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss
por: Olesen, Margrethe A., et al.
Publicado: (2020)

Effect of Alcohol on Hippocampal-Dependent Plasticity and Behavior: Role of Glutamatergic Synaptic Transmission
por: Mira, Rodrigo G., et al.
Publicado: (2020)

Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus
por: Jara, Claudia, et al.
Publicado: (2018)

Tau Deletion Prevents Cognitive Impairment and Mitochondrial Dysfunction Age Associated by a Mechanism Dependent on Cyclophilin-D
por: Jara, Claudia, et al.
Publicado: (2021)

Electroacupuncture at GV24 and bilateral GB13 improves cognitive ability via influences the levels of Aβ, p-tau (s396) and p-tau (s404) in the hippocampus of Alzheimer’s disease model rats
por: Yang, Yang, et al.
Publicado: (2020)

Hormetic-Like Effects of L-Homocysteine on Synaptic Structure, Function, and Aβ Aggregation
por: Montecinos-Oliva, Carla, et al.
Publicado: (2020)

Is L-methionine a trigger factor for Alzheimer’s-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice
por: Tapia-Rojas, Cheril, et al.
Publicado: (2015)

Ketamine induces tau hyperphosphorylation at serine 404 in the hippocampus of neonatal rats
por: Jin, Haiyan, et al.
Publicado: (2013)

Residue-based propensity of aggregation in the Tau amyloidogenic hexapeptides AcPHF6* and AcPHF6
por: Dangi, Abha, et al.
Publicado: (2020)

Neuroprotective Effect of AM404 Against NMDA-Induced Hippocampal Excitotoxicity
por: Saliba, Soraya Wilke, et al.
Publicado: (2019)

PHF-Core Tau as the Potential Initiating Event for Tau Pathology in Alzheimer’s Disease
por: Luna-Viramontes, Nabil Itzi, et al.
Publicado: (2020)

Correction: Residue-based propensity of aggregation in the Tau amyloidogenic hexapeptides AcPHF6* and AcPHF6
por: Dangi, Abha, et al.
Publicado: (2022)

Mitochondrial Bioenergetics, Redox Balance, and Calcium Homeostasis Dysfunction with Defective Ultrastructure and Quality Control in the Hippocampus of Aged Female C57BL/6J Mice
por: Torres, Angie K., et al.
Publicado: (2023)

Age-Dependent Behavioral and Synaptic Dysfunction Impairment Are Improved with Long-Term Andrographolide Administration in Long-Lived Female Degus (Octodon degus)
por: Oliva, Carolina A., et al.
Publicado: (2023)

The sequential phosphorylation of PHF10 subunit of the PBAF chromatin-remodeling complex determines different properties of the PHF10 isoforms
por: Sheynov, Andrey A., et al.
Publicado: (2020)

Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates
por: Cantrelle, François-Xavier, et al.
Publicado: (2021)

Selenoprotein P Regulates Synaptic Zinc and Reduces Tau Phosphorylation
por: Kiyohara, Arlene C. P., et al.
Publicado: (2021)

Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity
por: Barone, Ilaria, et al.
Publicado: (2023)

The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer’s Disease
por: Magistri, Marco, et al.
Publicado: (2016)

Die Wahrheit über die "404"
Publicado: (2009)

404. The occurrence of stroke in COVID-19
por: Wanahita, Anna, et al.
Publicado: (2020)

Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates
por: Maina, Mahmoud B., et al.
Publicado: (2021)

Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau
por: Rosenqvist, Nina, et al.
Publicado: (2018)

Evidence of Synaptic and Neurochemical Remodeling in the Retina of Aging Degus
por: Chang, Lily Y.-L., et al.
Publicado: (2020)

Hippocampal Synaptic Alterations Associated with Tau Pathology in Primary Age-Related Tauopathy
por: Morris, Meaghan, et al.
Publicado: (2023)

Erratum to ‘Association of the intraoperative peripheral perfusion index with postoperative morbidity and mortality in acute surgical patients: a retrospective observational multicentre cohort study’ (Br J Anaesth 2021; 127: 396-404)
por: Agerskov, Marianne, et al.
Publicado: (2022)

Fukutin regulates tau phosphorylation and synaptic function: Novel properties of fukutin in neurons
por: Tsukui, Ryota, et al.
Publicado: (2022)

Beta‐amyloid 1‐42 monomers, but not oligomers, produce PHF‐like conformation of Tau protein
por: Manassero, Giusi, et al.
Publicado: (2016)

Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids
por: KrishnaKumar, V. Guru, et al.
Publicado: (2018)

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau
por: Strang, Kevin H., et al.
Publicado: (2017)

Computational Insights Into the Inhibition Mechanism of Proanthocyanidin B2 on Tau Hexapeptide (PHF6) Oligomer
por: Li, Qin, et al.
Publicado: (2021)

Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1
por: Iijima-Ando, Kanae, et al.
Publicado: (2012)

The epigenetic reader PHF21B modulates murine social memory and synaptic plasticity–related genes
por: Chin, Eunice W.M., et al.
Publicado: (2022)

Internalization of the Extracellular Full-Length Tau Inside Neuro2A and Cortical Cells Is Enhanced by Phosphorylation
por: Wauters, Mathilde, et al.
Publicado: (2016)

Granulovacuolar Degenerations Appear in Relation to Hippocampal Phosphorylated Tau Accumulation in Various Neurodegenerative Disorders
por: Yamazaki, Yuu, et al.
Publicado: (2011)

Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic Mice
por: Houben, Sarah, et al.
Publicado: (2020)

Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease
por: Tapia-Rojas, Cheril, et al.
Publicado: (2018)

Review of the existing maximum residue levels for tau‐fluvalinate according to Article 12 of Regulation (EC) No 396/2005
por: Brancato, Alba, et al.
Publicado: (2018)

Stability of the PHF10 subunit of PBAF signature module is regulated by phosphorylation: role of β-TrCP
por: Tatarskiy, Victor V., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_4qqgkoknbosunhek4phed2vl3f