Proteolysis-targeting chimera against BCL-X(L) destroys tumor-infiltrating regulatory T cells

Regulatory T cells (Tregs) play an important role in maintaining immune homeostasis and, within tumors, their upregulation is common and promotes an immunosuppressive microenvironment. Therapeutic strategies that can eliminate Tregs in the tumor (i.e., therapies that do not run the risk of affecting...

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Detalles Bibliográficos
Autores principales: Kolb, Ryan, De, Umasankar, Khan, Sajid, Luo, Yuewan, Kim, Myung-Chul, Yu, Haijun, Wu, Chaoyan, Mo, Jiao, Zhang, Xin, Zhang, Peiyi, Zhang, Xuan, Borcherding, Nicholas, Koppel, Daniel, Fu, Yang-Xin, Zheng, Song Guo, Avram, Dorina, Zheng, Guangrong, Zhou, Daohong, Zhang, Weizhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904819/
https://www.ncbi.nlm.nih.gov/pubmed/33627663
http://dx.doi.org/10.1038/s41467-021-21573-x

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