Long runs of homozygosity are associated with Alzheimer’s disease

Long runs of homozygosity (ROH) are contiguous stretches of homozygous genotypes, which are a footprint of inbreeding and recessive inheritance. The presence of recessive loci is suggested for Alzheimer’s disease (AD); however, their search has been poorly assessed to date. To investigate homozygosi...

Descripción completa

Detalles Bibliográficos
Autores principales: Moreno-Grau, Sonia, Fernández, Maria Victoria, de Rojas, Itziar, Garcia-González, Pablo, Hernández, Isabel, Farias, Fabiana, Budde, John P., Quintela, Inés, Madrid, Laura, González-Pérez, Antonio, Montrreal, Laura, Alarcón-Martín, Emilio, Alegret, Montserrat, Maroñas, Olalla, Pineda, Juan Antonio, Macías, Juan, Marquié, Marta, Valero, Sergi, Benaque, Alba, Clarimón, Jordi, Bullido, Maria Jesus, García-Ribas, Guillermo, Pástor, Pau, Sánchez-Juan, Pascual, Álvarez, Victoria, Piñol-Ripoll, Gerard, García-Alberca, Jose María, Royo, José Luis, Franco-Macías, Emilio, Mir, Pablo, Calero, Miguel, Medina, Miguel, Rábano, Alberto, Ávila, Jesús, Antúnez, Carmen, Real, Luis Miguel, Orellana, Adelina, Carracedo, Ángel, Sáez, María Eugenia, Tárraga, Lluís, Boada, Mercè, Cruchaga, Carlos, Ruiz, Agustín
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904832/
https://www.ncbi.nlm.nih.gov/pubmed/33627629
http://dx.doi.org/10.1038/s41398-020-01145-1

Ejemplares similares

Ejemplares similares