Nanobody-based chimeric antigen receptor T cells designed by CRISPR/Cas9 technology for solid tumor immunotherapy

Chimeric antigen receptor-based T-cell immunotherapy is a promising strategy for treatment of hematological malignant tumors; however, its efficacy towards solid cancer remains challenging. We therefore focused on developing nanobody-based CAR-T cells that treat the solid tumor. CD105 expression is...

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Detalles Bibliográficos
Autores principales: Mo, Fengzhen, Duan, Siliang, Jiang, Xiaobing, Yang, Xiaomei, Hou, Xiaoqiong, Shi, Wei, Carlos, Cueva Jumbo Juan, Liu, Aiqun, Yin, Shihua, Wang, Wu, Yao, Hua, Yu, Zihang, Tang, Zhuoran, Xie, Shenxia, Ding, Ziqiang, Zhao, Xinyue, Hammock, Bruce D., Lu, Xiaoling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904846/
https://www.ncbi.nlm.nih.gov/pubmed/33627635
http://dx.doi.org/10.1038/s41392-021-00462-1

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