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The conditional deletion of steroidogenic factor 1 (Nr5a1) in Sox9-Cre mice compromises testis differentiation

Steroidogenic factor 1 (NR5A1) is essential for gonadal development. To study the importance of NR5A1 during early gonadal sex differentiation, we generated Sox9-Cre-Nr5a1 conditional knockout (cKO) mice: Sox9-Cre;Nr5a1(flox/flox) and Sox9-Cre;Nr5a1(flox/−) mice. Double-immunostaining for NR5A1 and...

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Detalles Bibliográficos
Autores principales:	Ikeda, Yayoi, Tagami, Ayako, Maekawa, Mamiko, Nagai, Akiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904858/ https://www.ncbi.nlm.nih.gov/pubmed/33627800 http://dx.doi.org/10.1038/s41598-021-84095-y

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