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Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

Niemann-Pick type C disease is a rare neurodegenerative disorder mainly caused by mutations in NPC1, resulting in abnormal late endosomal/lysosomal lipid storage. Although microgliosis is a prominent pathological feature, direct consequences of NPC1 loss on microglial function remain not fully chara...

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Detalles Bibliográficos
Autores principales:	Colombo, Alessio, Dinkel, Lina, Müller, Stephan A., Sebastian Monasor, Laura, Schifferer, Martina, Cantuti-Castelvetri, Ludovico, König, Jasmin, Vidatic, Lea, Bremova-Ertl, Tatiana, Lieberman, Andrew P., Hecimovic, Silva, Simons, Mikael, Lichtenthaler, Stefan F., Strupp, Michael, Schneider, Susanne A., Tahirovic, Sabina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904859/ https://www.ncbi.nlm.nih.gov/pubmed/33627648 http://dx.doi.org/10.1038/s41467-021-21428-5

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