An Inflammatory Loop Between Spleen-Derived Myeloid Cells and CD4(+) T Cells Leads to Accumulation of Long-Lived Plasma Cells That Exacerbates Lupus Autoimmunity

Splenic long-lived plasma cells are abnormally numerous and deleterious in systemic autoimmune diseases, yet how they accumulate remains poorly understood. We demonstrate here that a pathological role of spleen-derived CD11b(+)Gr-1(+) myeloid cells (SDMCs) underpins the accumulation of splenic long-...

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Detalles Bibliográficos
Autores principales: Jang, Eunkyeong, Cho, Somi, Pyo, Sungjin, Nam, Jin-Wu, Youn, Jeehee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904883/
https://www.ncbi.nlm.nih.gov/pubmed/33643317
http://dx.doi.org/10.3389/fimmu.2021.631472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904883/
https://www.ncbi.nlm.nih.gov/pubmed/33643317
http://dx.doi.org/10.3389/fimmu.2021.631472

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