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An Inflammatory Loop Between Spleen-Derived Myeloid Cells and CD4(+) T Cells Leads to Accumulation of Long-Lived Plasma Cells That Exacerbates Lupus Autoimmunity
Splenic long-lived plasma cells are abnormally numerous and deleterious in systemic autoimmune diseases, yet how they accumulate remains poorly understood. We demonstrate here that a pathological role of spleen-derived CD11b(+)Gr-1(+) myeloid cells (SDMCs) underpins the accumulation of splenic long-...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904883/ https://www.ncbi.nlm.nih.gov/pubmed/33643317 http://dx.doi.org/10.3389/fimmu.2021.631472 |