Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9

Changes in glycosylation during tumour progression are a key hallmark of cancer. One of the glycan moieties generally overexpressed in cancer are sialic acids, which can induce immunomodulatory properties via binding to Siglec receptors. We here show that Pancreatic Ductal Adenocarcinoma (PDAC) tumo...

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Detalles Bibliográficos
Autores principales: Rodriguez, Ernesto, Boelaars, Kelly, Brown, Kari, Eveline Li, R. J., Kruijssen, Laura, Bruijns, Sven C. M., van Ee, Thomas, Schetters, Sjoerd T. T., Crommentuijn, Matheus H. W., van der Horst, Joost C., van Grieken, Nicole C. T., van Vliet, Sandra J., Kazemier, Geert, Giovannetti, Elisa, Garcia-Vallejo, Juan J., van Kooyk, Yvette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904912/
https://www.ncbi.nlm.nih.gov/pubmed/33627655
http://dx.doi.org/10.1038/s41467-021-21550-4

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