Highly dampened blood transcriptome response in HIV patients after respiratory infection

Respiratory viral (RV) infections represent a major threat for human health worldwide. Persons with HIV (PWH) have a compromised immune response and are thought to be at higher risk for severe RV disease. However, very little is known about the host immune response to RV infection in PWH. Here, we i...

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Autores principales: Sellers, Subhashini A., Fischer, William A., Heise, Mark T., Schughart, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904929/
https://www.ncbi.nlm.nih.gov/pubmed/33627703
http://dx.doi.org/10.1038/s41598-021-83876-9
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author Sellers, Subhashini A.
Fischer, William A.
Heise, Mark T.
Schughart, Klaus
author_facet Sellers, Subhashini A.
Fischer, William A.
Heise, Mark T.
Schughart, Klaus
author_sort Sellers, Subhashini A.
collection PubMed
description Respiratory viral (RV) infections represent a major threat for human health worldwide. Persons with HIV (PWH) have a compromised immune response and are thought to be at higher risk for severe RV disease. However, very little is known about the host immune response to RV infection in PWH. Here, we investigated gene expression changes in the peripheral blood of PWH co-infected with RV. Only very few differentially expressed genes could be detected between PWH with and without RV infection, suggesting that the immune response to RV in PWH is strongly dampened. Our data provides important insights into the host response to RV infections in HIV patients.
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spelling pubmed-79049292021-02-25 Highly dampened blood transcriptome response in HIV patients after respiratory infection Sellers, Subhashini A. Fischer, William A. Heise, Mark T. Schughart, Klaus Sci Rep Article Respiratory viral (RV) infections represent a major threat for human health worldwide. Persons with HIV (PWH) have a compromised immune response and are thought to be at higher risk for severe RV disease. However, very little is known about the host immune response to RV infection in PWH. Here, we investigated gene expression changes in the peripheral blood of PWH co-infected with RV. Only very few differentially expressed genes could be detected between PWH with and without RV infection, suggesting that the immune response to RV in PWH is strongly dampened. Our data provides important insights into the host response to RV infections in HIV patients. Nature Publishing Group UK 2021-02-24 /pmc/articles/PMC7904929/ /pubmed/33627703 http://dx.doi.org/10.1038/s41598-021-83876-9 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Sellers, Subhashini A.
Fischer, William A.
Heise, Mark T.
Schughart, Klaus
Highly dampened blood transcriptome response in HIV patients after respiratory infection
title Highly dampened blood transcriptome response in HIV patients after respiratory infection
title_full Highly dampened blood transcriptome response in HIV patients after respiratory infection
title_fullStr Highly dampened blood transcriptome response in HIV patients after respiratory infection
title_full_unstemmed Highly dampened blood transcriptome response in HIV patients after respiratory infection
title_short Highly dampened blood transcriptome response in HIV patients after respiratory infection
title_sort highly dampened blood transcriptome response in hiv patients after respiratory infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904929/
https://www.ncbi.nlm.nih.gov/pubmed/33627703
http://dx.doi.org/10.1038/s41598-021-83876-9
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