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Uncharted territories in the discovery of antifungal and antivirulence natural products from bacteria

Many fungi can cause deadly diseases in humans, and nearly every human will suffer from some kind of fungal infection in their lives. Only few antifungals are available, and some of these fail to treat intrinsically resistant species and the ever-increasing number of fungal strains that have acquire...

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Detalles Bibliográficos
Autores principales: Vij, Raghav, Hube, Bernhard, Brunke, Sascha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905183/
https://www.ncbi.nlm.nih.gov/pubmed/33680363
http://dx.doi.org/10.1016/j.csbj.2021.02.003
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author Vij, Raghav
Hube, Bernhard
Brunke, Sascha
author_facet Vij, Raghav
Hube, Bernhard
Brunke, Sascha
author_sort Vij, Raghav
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description Many fungi can cause deadly diseases in humans, and nearly every human will suffer from some kind of fungal infection in their lives. Only few antifungals are available, and some of these fail to treat intrinsically resistant species and the ever-increasing number of fungal strains that have acquired resistance. In nature, bacteria and fungi display versatile interactions that range from friendly co-existence to predation. The first antifungal drugs, nystatin and amphotericin B, were discovered in bacteria as mediators of such interactions, and bacteria continue to be an important source of antifungals. To learn more about the ecological bacterial-fungal interactions that drive the evolution of natural products and exploit them, we need to identify environments where such interactions are pronounced, and diverse. Here, we systematically analyze historic and recent developments in this field to identify potentially under-investigated niches and resources. We also discuss alternative strategies to treat fungal infections by utilizing the antagonistic potential of bacteria to target fungal stress pathways and virulence factors, and thereby suppress the evolution of antifungal resistance.
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spelling pubmed-79051832021-03-04 Uncharted territories in the discovery of antifungal and antivirulence natural products from bacteria Vij, Raghav Hube, Bernhard Brunke, Sascha Comput Struct Biotechnol J Review Article Many fungi can cause deadly diseases in humans, and nearly every human will suffer from some kind of fungal infection in their lives. Only few antifungals are available, and some of these fail to treat intrinsically resistant species and the ever-increasing number of fungal strains that have acquired resistance. In nature, bacteria and fungi display versatile interactions that range from friendly co-existence to predation. The first antifungal drugs, nystatin and amphotericin B, were discovered in bacteria as mediators of such interactions, and bacteria continue to be an important source of antifungals. To learn more about the ecological bacterial-fungal interactions that drive the evolution of natural products and exploit them, we need to identify environments where such interactions are pronounced, and diverse. Here, we systematically analyze historic and recent developments in this field to identify potentially under-investigated niches and resources. We also discuss alternative strategies to treat fungal infections by utilizing the antagonistic potential of bacteria to target fungal stress pathways and virulence factors, and thereby suppress the evolution of antifungal resistance. Research Network of Computational and Structural Biotechnology 2021-02-11 /pmc/articles/PMC7905183/ /pubmed/33680363 http://dx.doi.org/10.1016/j.csbj.2021.02.003 Text en © 2021 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Vij, Raghav
Hube, Bernhard
Brunke, Sascha
Uncharted territories in the discovery of antifungal and antivirulence natural products from bacteria
title Uncharted territories in the discovery of antifungal and antivirulence natural products from bacteria
title_full Uncharted territories in the discovery of antifungal and antivirulence natural products from bacteria
title_fullStr Uncharted territories in the discovery of antifungal and antivirulence natural products from bacteria
title_full_unstemmed Uncharted territories in the discovery of antifungal and antivirulence natural products from bacteria
title_short Uncharted territories in the discovery of antifungal and antivirulence natural products from bacteria
title_sort uncharted territories in the discovery of antifungal and antivirulence natural products from bacteria
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905183/
https://www.ncbi.nlm.nih.gov/pubmed/33680363
http://dx.doi.org/10.1016/j.csbj.2021.02.003
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