Chloroquine ameliorates bone loss induced by d-galactose in male rats via inhibition of ERK associated osteoclastogenesis and antioxidant effect

Chloroquine (CQ); a lysosomotropic agent used for decade ago as anti-malarial, was tested against aging induced osteoporosis. Osteoporosis in male rats was induced using d-galactose (D-gal) as a reducing sugar at a dose of 200 mg/kg/day; i.p. Osteoporotic rats were orally treated with CQ (10 mg/kg/d...

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Detalles Bibliográficos
Autores principales: Mahmoud, Mohamed A. Aziz, Saleh, Dalia O., Safar, Marwa M., Agha, Azza M., Khattab, Mahmoud M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905189/
https://www.ncbi.nlm.nih.gov/pubmed/33665135
http://dx.doi.org/10.1016/j.toxrep.2021.02.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905189/
https://www.ncbi.nlm.nih.gov/pubmed/33665135
http://dx.doi.org/10.1016/j.toxrep.2021.02.007

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