UVA-Triggered Drug Release and Photo-Protection of Skin

Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light stimuli to control the release of drugs using a “s...

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Autores principales: Karisma, Vega Widya, Wu, Wei, Lei, Mingxing, Liu, Huawen, Nisar, Muhammad Farrukh, Lloyd, Matthew D., Pourzand, Charareh, Zhong, Julia Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905215/
https://www.ncbi.nlm.nih.gov/pubmed/33644041
http://dx.doi.org/10.3389/fcell.2021.598717
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author Karisma, Vega Widya
Wu, Wei
Lei, Mingxing
Liu, Huawen
Nisar, Muhammad Farrukh
Lloyd, Matthew D.
Pourzand, Charareh
Zhong, Julia Li
author_facet Karisma, Vega Widya
Wu, Wei
Lei, Mingxing
Liu, Huawen
Nisar, Muhammad Farrukh
Lloyd, Matthew D.
Pourzand, Charareh
Zhong, Julia Li
author_sort Karisma, Vega Widya
collection PubMed
description Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light stimuli to control the release of drugs using a “switch on- switch off” procedure. This review discusses the promising potential of UVA radiation as the light source of choice for photo-controlled drug release from a range of photo-responsive and photolabile nanostructures via photo-isomerization, photo-cleavage, photo-crosslinking, and photo-induced rearrangement. In addition to its clinical use, we will also provide here an overview of the recent UVA-responsive drug release approaches that are developed for phototherapy and skin photoprotection.
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spelling pubmed-79052152021-02-26 UVA-Triggered Drug Release and Photo-Protection of Skin Karisma, Vega Widya Wu, Wei Lei, Mingxing Liu, Huawen Nisar, Muhammad Farrukh Lloyd, Matthew D. Pourzand, Charareh Zhong, Julia Li Front Cell Dev Biol Cell and Developmental Biology Light has attracted special attention as a stimulus for triggered drug delivery systems (DDS) due to its intrinsic features of being spatially and temporally tunable. Ultraviolet A (UVA) radiation has recently been used as a source of external light stimuli to control the release of drugs using a “switch on- switch off” procedure. This review discusses the promising potential of UVA radiation as the light source of choice for photo-controlled drug release from a range of photo-responsive and photolabile nanostructures via photo-isomerization, photo-cleavage, photo-crosslinking, and photo-induced rearrangement. In addition to its clinical use, we will also provide here an overview of the recent UVA-responsive drug release approaches that are developed for phototherapy and skin photoprotection. Frontiers Media S.A. 2021-02-11 /pmc/articles/PMC7905215/ /pubmed/33644041 http://dx.doi.org/10.3389/fcell.2021.598717 Text en Copyright © 2021 Karisma, Wu, Lei, Liu, Nisar, Lloyd, Pourzand and Zhong. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Karisma, Vega Widya
Wu, Wei
Lei, Mingxing
Liu, Huawen
Nisar, Muhammad Farrukh
Lloyd, Matthew D.
Pourzand, Charareh
Zhong, Julia Li
UVA-Triggered Drug Release and Photo-Protection of Skin
title UVA-Triggered Drug Release and Photo-Protection of Skin
title_full UVA-Triggered Drug Release and Photo-Protection of Skin
title_fullStr UVA-Triggered Drug Release and Photo-Protection of Skin
title_full_unstemmed UVA-Triggered Drug Release and Photo-Protection of Skin
title_short UVA-Triggered Drug Release and Photo-Protection of Skin
title_sort uva-triggered drug release and photo-protection of skin
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905215/
https://www.ncbi.nlm.nih.gov/pubmed/33644041
http://dx.doi.org/10.3389/fcell.2021.598717
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