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Recent advances in the development of nanomedicines for the treatment of ischemic stroke

Ischemic stroke is still a serious threat to human life and health, but there are few therapeutic options available to treat stroke because of limited blood-brain penetration. The development of nanotechnology may overcome some of the problems related to traditional drug development. In this review,...

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Autores principales: Tian, Xing, Fan, Taojian, Zhao, Wentian, Abbas, Ghulam, Han, Bo, Zhang, Ke, Li, Nan, Liu, Ning, Liang, Weiyuan, Huang, Hao, Chen, Wen, Wang, Bing, Xie, Zhongjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905263/
https://www.ncbi.nlm.nih.gov/pubmed/33718667
http://dx.doi.org/10.1016/j.bioactmat.2021.01.023
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author Tian, Xing
Fan, Taojian
Zhao, Wentian
Abbas, Ghulam
Han, Bo
Zhang, Ke
Li, Nan
Liu, Ning
Liang, Weiyuan
Huang, Hao
Chen, Wen
Wang, Bing
Xie, Zhongjian
author_facet Tian, Xing
Fan, Taojian
Zhao, Wentian
Abbas, Ghulam
Han, Bo
Zhang, Ke
Li, Nan
Liu, Ning
Liang, Weiyuan
Huang, Hao
Chen, Wen
Wang, Bing
Xie, Zhongjian
author_sort Tian, Xing
collection PubMed
description Ischemic stroke is still a serious threat to human life and health, but there are few therapeutic options available to treat stroke because of limited blood-brain penetration. The development of nanotechnology may overcome some of the problems related to traditional drug development. In this review, we focus on the potential applications of nanotechnology in stroke. First, we will discuss the main molecular pathological mechanisms of ischemic stroke to develop a targeted strategy. Second, considering the important role of the blood-brain barrier in stroke treatment, we also delve mechanisms by which the blood-brain barrier protects the brain, and the reasons why the therapeutics must pass through the blood-brain barrier to achieve efficacy. Lastly, we provide a comprehensive review related to the application of nanomaterials to treat stroke, including liposomes, polymers, metal nanoparticles, carbon nanotubes, graphene, black phosphorus, hydrogels and dendrimers. To conclude, we will summarize the challenges and future prospects of nanomedicine-based stroke treatments.
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spelling pubmed-79052632021-03-12 Recent advances in the development of nanomedicines for the treatment of ischemic stroke Tian, Xing Fan, Taojian Zhao, Wentian Abbas, Ghulam Han, Bo Zhang, Ke Li, Nan Liu, Ning Liang, Weiyuan Huang, Hao Chen, Wen Wang, Bing Xie, Zhongjian Bioact Mater Article Ischemic stroke is still a serious threat to human life and health, but there are few therapeutic options available to treat stroke because of limited blood-brain penetration. The development of nanotechnology may overcome some of the problems related to traditional drug development. In this review, we focus on the potential applications of nanotechnology in stroke. First, we will discuss the main molecular pathological mechanisms of ischemic stroke to develop a targeted strategy. Second, considering the important role of the blood-brain barrier in stroke treatment, we also delve mechanisms by which the blood-brain barrier protects the brain, and the reasons why the therapeutics must pass through the blood-brain barrier to achieve efficacy. Lastly, we provide a comprehensive review related to the application of nanomaterials to treat stroke, including liposomes, polymers, metal nanoparticles, carbon nanotubes, graphene, black phosphorus, hydrogels and dendrimers. To conclude, we will summarize the challenges and future prospects of nanomedicine-based stroke treatments. KeAi Publishing 2021-02-20 /pmc/articles/PMC7905263/ /pubmed/33718667 http://dx.doi.org/10.1016/j.bioactmat.2021.01.023 Text en © 2021 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Tian, Xing
Fan, Taojian
Zhao, Wentian
Abbas, Ghulam
Han, Bo
Zhang, Ke
Li, Nan
Liu, Ning
Liang, Weiyuan
Huang, Hao
Chen, Wen
Wang, Bing
Xie, Zhongjian
Recent advances in the development of nanomedicines for the treatment of ischemic stroke
title Recent advances in the development of nanomedicines for the treatment of ischemic stroke
title_full Recent advances in the development of nanomedicines for the treatment of ischemic stroke
title_fullStr Recent advances in the development of nanomedicines for the treatment of ischemic stroke
title_full_unstemmed Recent advances in the development of nanomedicines for the treatment of ischemic stroke
title_short Recent advances in the development of nanomedicines for the treatment of ischemic stroke
title_sort recent advances in the development of nanomedicines for the treatment of ischemic stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905263/
https://www.ncbi.nlm.nih.gov/pubmed/33718667
http://dx.doi.org/10.1016/j.bioactmat.2021.01.023
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