Inhibition of miR-199a-5p rejuvenates aged mesenchymal stem cells derived from patients with idiopathic pulmonary fibrosis and improves their therapeutic efficacy in experimental pulmonary fibrosis

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is an age-related disease with no cure. Mesenchymal stem cell (MSC)-based therapy has emerged as a novel strategy for IPF treatment. Nevertheless, MSCs derived from patients with IPF (IPF-MSCs) become senescent, thereby reducing their beneficial effect...

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Detalles Bibliográficos
Autores principales: Shi, Linli, Han, Qian, Hong, Yimei, Li, Weifeng, Gong, Gencheng, Cui, Jiangyu, Mao, Mengmeng, Liang, Xiaoting, Hu, Bei, Li, Xin, Luo, Qun, Zhang, Yuelin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905557/
https://www.ncbi.nlm.nih.gov/pubmed/33632305
http://dx.doi.org/10.1186/s13287-021-02215-x

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