Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities

Controlling the activation of the NLRP3 inflammasome by post-translational modifications (PTMs) of critical protein subunits has emerged as a key determinant in inflammatory processes as well as in pathophysiology. In this review, we put into context the kinases, ubiquitin processing and other PTM e...

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Autores principales: Liang, Zhu, Damianou, Andreas, Di Daniel, Elena, Kessler, Benedikt M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905589/
https://www.ncbi.nlm.nih.gov/pubmed/33627128
http://dx.doi.org/10.1186/s12964-020-00688-6
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author Liang, Zhu
Damianou, Andreas
Di Daniel, Elena
Kessler, Benedikt M.
author_facet Liang, Zhu
Damianou, Andreas
Di Daniel, Elena
Kessler, Benedikt M.
author_sort Liang, Zhu
collection PubMed
description Controlling the activation of the NLRP3 inflammasome by post-translational modifications (PTMs) of critical protein subunits has emerged as a key determinant in inflammatory processes as well as in pathophysiology. In this review, we put into context the kinases, ubiquitin processing and other PTM enzymes that modify NLRP3, ASC/PYCARD and caspase-1, leading to inflammasome regulation, activation and signal termination. Potential target therapeutic entry points for a number of inflammatory diseases focussed on PTM enzyme readers, writers and erasers, leading to the regulation of inflammasome function, are discussed.
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spelling pubmed-79055892021-02-25 Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities Liang, Zhu Damianou, Andreas Di Daniel, Elena Kessler, Benedikt M. Cell Commun Signal Review Controlling the activation of the NLRP3 inflammasome by post-translational modifications (PTMs) of critical protein subunits has emerged as a key determinant in inflammatory processes as well as in pathophysiology. In this review, we put into context the kinases, ubiquitin processing and other PTM enzymes that modify NLRP3, ASC/PYCARD and caspase-1, leading to inflammasome regulation, activation and signal termination. Potential target therapeutic entry points for a number of inflammatory diseases focussed on PTM enzyme readers, writers and erasers, leading to the regulation of inflammasome function, are discussed. BioMed Central 2021-02-24 /pmc/articles/PMC7905589/ /pubmed/33627128 http://dx.doi.org/10.1186/s12964-020-00688-6 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Liang, Zhu
Damianou, Andreas
Di Daniel, Elena
Kessler, Benedikt M.
Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities
title Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities
title_full Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities
title_fullStr Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities
title_full_unstemmed Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities
title_short Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities
title_sort inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905589/
https://www.ncbi.nlm.nih.gov/pubmed/33627128
http://dx.doi.org/10.1186/s12964-020-00688-6
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