Cargando…

Simvastatin impairs hippocampal synaptic plasticity and cognitive function in mice

Lipophilic statins which are blood brain barrier (BBB) permeable are speculated to affect the cholesterol synthesis and neural functions in the central nervous system. However, whether these statins can affect cholesterol levels and synaptic plasticity in hippocampus and the in vivo consequence rema...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Yujun, Zou, Guichang, Qi, Keke, Jin, Jin, Yao, Lei, Pan, Yang, Xiong, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905661/ https://www.ncbi.nlm.nih.gov/pubmed/33627175 http://dx.doi.org/10.1186/s13041-021-00758-x

Ejemplares similares

Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice
por: Liu, Yi, et al.
Publicado: (2018)

Abnormal synaptic plasticity and impaired cognition in schizophrenia
por: Wu, Xiu-Lin, et al.
Publicado: (2022)

Molecular mechanisms for simvastatin-mediated enhancement of synaptic plasticity
por: Mans, Robert A, et al.
Publicado: (2012)

Nxf7 deficiency impairs social exploration and spatio-cognitive abilities as well as hippocampal synaptic plasticity in mice
por: Callaerts-Vegh, Zsuzsanna, et al.
Publicado: (2015)

Contribution of Hypothyroidism to Cognitive Impairment and Hippocampal Synaptic Plasticity Regulation in an Animal Model of Depression
por: Głombik, Katarzyna, et al.
Publicado: (2021)

Simvastatin Attenuates Hippocampal MMP-9 Expression in the Streptozotocin-Induced Cognitive Impairment
por: Adeli, Soheila, et al.
Publicado: (2019)

Memory and synaptic plasticity are impaired by dysregulated hippocampal O-GlcNAcylation
por: Yang, Yong Ryoul, et al.
Publicado: (2017)

Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function
por: Wu, Min-Yi, et al.
Publicado: (2022)

Young plasma reverses anesthesia and surgery-induced cognitive impairment in aged rats by modulating hippocampal synaptic plasticity
por: Li, Yanan, et al.
Publicado: (2022)

Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity
por: Grillo, Claudia A., et al.
Publicado: (2015)

Impaired Learning and Memory Ability Induced by a Bilaterally Hippocampal Injection of Streptozotocin in Mice: Involved With the Adaptive Changes of Synaptic Plasticity
por: Qi, Cong-Cong, et al.
Publicado: (2021)

Impaired Cognitive Function and Altered Hippocampal Synaptic Plasticity in Mice Lacking Dermatan Sulfotransferase Chst14/D4st1
por: Li, Qifa, et al.
Publicado: (2019)

High Frequency Repetitive Transcranial Magnetic Stimulation Alleviates Cognitive Impairment and Modulates Hippocampal Synaptic Structural Plasticity in Aged Mice
por: Ma, Qinying, et al.
Publicado: (2019)

Electroacupuncture Increases the Hippocampal Synaptic Transmission Efficiency and Long-Term Plasticity to Improve Vascular Cognitive Impairment
por: Dai, Yaling, et al.
Publicado: (2022)

Unconjugated Bilirubin Exposure Impairs Hippocampal Long-Term Synaptic Plasticity
por: Chang, Fang-Yu, et al.
Publicado: (2009)

Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats
por: Arias-Cavieres, Alejandra, et al.
Publicado: (2018)

ATP11B deficiency leads to impairment of hippocampal synaptic plasticity
por: Wang, Jiao, et al.
Publicado: (2019)

Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice
por: Rong, Jing, et al.
Publicado: (2023)

Effects of dihydrotestosterone on synaptic plasticity of the hippocampus in mild cognitive impairment male SAMP8 mice
por: Pan, Wensen, et al.
Publicado: (2016)

Impaired Insulin Signaling Alters Mediators of Hippocampal Synaptic Dynamics/Plasticity: A Possible Mechanism of Hyperglycemia-Induced Cognitive Impairment
por: Ansari, Mubeen A., et al.
Publicado: (2023)

Early Life Febrile Seizures Impair Hippocampal Synaptic Plasticity in Young Rats
por: Postnikova, Tatyana Y., et al.
Publicado: (2021)

Pannexin 1 regulates bidirectional hippocampal synaptic plasticity in adult mice
por: Ardiles, Alvaro O., et al.
Publicado: (2014)

Prolactin enhances hippocampal synaptic plasticity in female mice of reproductive age
por: Zamora‐Moratalla, Alfonsa, et al.
Publicado: (2020)

Electroacupuncture Ameliorates Cognitive Deficit and Improves Hippocampal Synaptic Plasticity in Adult Rat with Neonatal Maternal Separation
por: Guo, Lili, et al.
Publicado: (2018)

Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1
por: Parkinson, Pamela F, et al.
Publicado: (2009)

Enhanced ventral hippocampal synaptic transmission and impaired synaptic plasticity in a rodent model of alcohol addiction vulnerability
por: Almonte, Antoine G., et al.
Publicado: (2017)

Involvement of Paired Immunoglobulin-Like Receptor B in Cognitive Dysfunction Through Hippocampal-Dependent Synaptic Plasticity Impairments in Mice Subjected to Chronic Sleep Restriction
por: Li, Xuying, et al.
Publicado: (2022)

IL-33 Alleviates Postoperative Cognitive Impairment by Inhibiting Hippocampal Inflammation and Upregulating Excitatory Synaptic Number in Aged Mice
por: Li, Qi, et al.
Publicado: (2022)

Neuromodulation of hippocampal long-term synaptic plasticity
por: Palacios-Filardo, Jon, et al.
Publicado: (2019)

How do Soluble Oligomers of Amyloid β-protein Impair Hippocampal Synaptic Plasticity?
por: Li, Shaomin, et al.
Publicado: (2010)

Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity
por: Nomoto, Masanori, et al.
Publicado: (2012)

Effects of Calcium on Drinking Fluorosis-induced Hippocampal Synaptic Plasticity Impairment in the Offspring of Rats
por: Zigu, Zhang, et al.
Publicado: (2017)

Delayed Impairment of Hippocampal Synaptic Plasticity after Pentylenetetrazole-Induced Seizures in Young Rats
por: Postnikova, Tatyana Y., et al.
Publicado: (2022)

Umbelliferone Ameliorates Memory Impairment and Enhances Hippocampal Synaptic Plasticity in Scopolamine-Induced Rat Model
por: Choi, Ga-Young, et al.
Publicado: (2023)

The requirement of BDNF for hippocampal synaptic plasticity is experience‐dependent
por: Aarse, Janna, et al.
Publicado: (2016)

Bidirectional synaptic plasticity rapidly modifies hippocampal representations
por: Milstein, Aaron D, et al.
Publicado: (2021)

Investigation of hippocampal synaptic transmission and plasticity in mice deficient in the actin-binding protein Drebrin
por: Willmes, Claudia G., et al.
Publicado: (2017)

Pumilio2 regulates synaptic plasticity via translational repression of synaptic receptors in mice
por: Dong, Hongxin, et al.
Publicado: (2018)

Curcumin alleviates orofacial allodynia and improves cognitive impairment via regulating hippocampal synaptic plasticity in a mouse model of trigeminal neuralgia
por: Zhi, Hong-Wei, et al.
Publicado: (2023)

The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory
por: Marciniak, Elodie, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_h8nr7m9okmi29020ogc32vfame