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REM Sleep Behavior Disorder in Children With Type 1 Narcolepsy Treated With Sodium Oxybate
OBJECTIVE: To study the effect of stable treatment with sodium oxybate (SO) on nocturnal REM sleep behavior disorder (RBD) and REM sleep without atonia (RSWA) that severely affected children with type 1 narcolepsy (NT1). METHODS: Nineteen children and adolescents with NT1 (9 female, mean age 12.5 ±...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905776/ https://www.ncbi.nlm.nih.gov/pubmed/33177222 http://dx.doi.org/10.1212/WNL.0000000000011157 |
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author | Antelmi, Elena Filardi, Marco Pizza, Fabio Vandi, Stefano Moresco, Monica Franceschini, Christian Tinazzi, Michele Ferri, Raffaele Plazzi, Giuseppe |
author_facet | Antelmi, Elena Filardi, Marco Pizza, Fabio Vandi, Stefano Moresco, Monica Franceschini, Christian Tinazzi, Michele Ferri, Raffaele Plazzi, Giuseppe |
author_sort | Antelmi, Elena |
collection | PubMed |
description | OBJECTIVE: To study the effect of stable treatment with sodium oxybate (SO) on nocturnal REM sleep behavior disorder (RBD) and REM sleep without atonia (RSWA) that severely affected children with type 1 narcolepsy (NT1). METHODS: Nineteen children and adolescents with NT1 (9 female, mean age 12.5 ± 2.7 years, mean disease duration 3.4 ± 1.6 years) underwent neurologic investigations and video-polysomnography (v-PSG) at baseline and after 3 months of stable treatment with SO. v-PSG was independently analyzed by 2 sleep experts to rate RBD episodes. RSWA was automatically computed by means of the validated REM sleep atonia index (RAI). RESULTS: Compared to baseline, RAI significantly improved (p < 0.05) and complex movements during REM sleep were remarkably reduced after stable treatment with SO. Compared to baseline, children also reported improvement in clinical complaints and showed a different nighttime sleep-stage architecture. CONCLUSIONS: RBD and RSWA improved after treatment with SO, pointing to a direct role of the drug in modulating motor control during REM sleep. CLASSIFICATION OF EVIDENCE: This study offers Class IV evidence of the positive effect of SO on modulation of muscle atonia during REM sleep in children with NT1 because of the absence of a control group. |
format | Online Article Text |
id | pubmed-7905776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-79057762021-05-12 REM Sleep Behavior Disorder in Children With Type 1 Narcolepsy Treated With Sodium Oxybate Antelmi, Elena Filardi, Marco Pizza, Fabio Vandi, Stefano Moresco, Monica Franceschini, Christian Tinazzi, Michele Ferri, Raffaele Plazzi, Giuseppe Neurology Article OBJECTIVE: To study the effect of stable treatment with sodium oxybate (SO) on nocturnal REM sleep behavior disorder (RBD) and REM sleep without atonia (RSWA) that severely affected children with type 1 narcolepsy (NT1). METHODS: Nineteen children and adolescents with NT1 (9 female, mean age 12.5 ± 2.7 years, mean disease duration 3.4 ± 1.6 years) underwent neurologic investigations and video-polysomnography (v-PSG) at baseline and after 3 months of stable treatment with SO. v-PSG was independently analyzed by 2 sleep experts to rate RBD episodes. RSWA was automatically computed by means of the validated REM sleep atonia index (RAI). RESULTS: Compared to baseline, RAI significantly improved (p < 0.05) and complex movements during REM sleep were remarkably reduced after stable treatment with SO. Compared to baseline, children also reported improvement in clinical complaints and showed a different nighttime sleep-stage architecture. CONCLUSIONS: RBD and RSWA improved after treatment with SO, pointing to a direct role of the drug in modulating motor control during REM sleep. CLASSIFICATION OF EVIDENCE: This study offers Class IV evidence of the positive effect of SO on modulation of muscle atonia during REM sleep in children with NT1 because of the absence of a control group. Lippincott Williams & Wilkins 2021-01-12 /pmc/articles/PMC7905776/ /pubmed/33177222 http://dx.doi.org/10.1212/WNL.0000000000011157 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Article Antelmi, Elena Filardi, Marco Pizza, Fabio Vandi, Stefano Moresco, Monica Franceschini, Christian Tinazzi, Michele Ferri, Raffaele Plazzi, Giuseppe REM Sleep Behavior Disorder in Children With Type 1 Narcolepsy Treated With Sodium Oxybate |
title | REM Sleep Behavior Disorder in Children With Type 1 Narcolepsy Treated With Sodium Oxybate |
title_full | REM Sleep Behavior Disorder in Children With Type 1 Narcolepsy Treated With Sodium Oxybate |
title_fullStr | REM Sleep Behavior Disorder in Children With Type 1 Narcolepsy Treated With Sodium Oxybate |
title_full_unstemmed | REM Sleep Behavior Disorder in Children With Type 1 Narcolepsy Treated With Sodium Oxybate |
title_short | REM Sleep Behavior Disorder in Children With Type 1 Narcolepsy Treated With Sodium Oxybate |
title_sort | rem sleep behavior disorder in children with type 1 narcolepsy treated with sodium oxybate |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905776/ https://www.ncbi.nlm.nih.gov/pubmed/33177222 http://dx.doi.org/10.1212/WNL.0000000000011157 |
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