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Gait-speed and oxygen flow during six-minute walk test predicts mortality in patients with advanced lung disease

The six-minute walk test (6MWT) is a useful tool to predict outcomes in patients with advanced lung diseases. Greater distance walked has been shown to have independent prognostic value. We reviewed the medical records of 164 patients with advanced lung disease who underwent lung transplant evaluati...

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Autores principales: Timofte, Irina, Tonelli, Adriano, Diaz-Abad, Montserrat, Verceles, Avelino, Ladikos, Nicholas, Iacono, Aldo, Terrin, Michael L., Wijesinha, Marniker, Akindipe, Olufemi, Baz, Maher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905842/
https://www.ncbi.nlm.nih.gov/pubmed/32072801
http://dx.doi.org/10.4081/monaldi.2020.1186
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author Timofte, Irina
Tonelli, Adriano
Diaz-Abad, Montserrat
Verceles, Avelino
Ladikos, Nicholas
Iacono, Aldo
Terrin, Michael L.
Wijesinha, Marniker
Akindipe, Olufemi
Baz, Maher
author_facet Timofte, Irina
Tonelli, Adriano
Diaz-Abad, Montserrat
Verceles, Avelino
Ladikos, Nicholas
Iacono, Aldo
Terrin, Michael L.
Wijesinha, Marniker
Akindipe, Olufemi
Baz, Maher
author_sort Timofte, Irina
collection PubMed
description The six-minute walk test (6MWT) is a useful tool to predict outcomes in patients with advanced lung diseases. Greater distance walked has been shown to have independent prognostic value. We reviewed the medical records of 164 patients with advanced lung disease who underwent lung transplant evaluation. Results of the 6MWT (distance walked, oxygen required to maintain oxygen saturation >90%, and gait speed) were recorded and analyzed with respect to mortality. 6MWT mean oxygen (O(2)) flow via nasal cannula was 3.5±3.7 1/min. The distance walked in meters (m) and percent predicted distance were inversely associated with mortality, hazard ratio (HR): 0.995 per meter (95% CI 0.992–0.998) for walk distance in meters and 0.970 per % predicted distance (95% CI 0.950–0.990). Patients who walked <200 meters [HR: 2.1 (95% CI 1.1–4.0)] or <45% of predicted, HR: 2.7 (95% CI 1.2–5.7) had higher mortality. O(2) flow during the test had a direct association with mortality (HR: 1.1 per L/min (95% CI 1.0–1.2). In multivariate analysis, O(2) flow >3.5 L/min remained predictive of mortality, HR: 1.1 per 1/min (95% CI 1.0–1.2). Gait speed was higher in patients who survived through follow-up compared to patients who died (mean 0.83±0.35 m/s vs 0.69±0.33 m/s, p=0.03). Gait speed >0.8 m/s was a predictor of survival, HR 3.4 (1.1, 10.6). In summary, distance walked and O(2) flow during the 6MWT were predictors of mortality in patients with advanced lung disease. Patients who required more than 3.5 1/m of O(2) to maintain oxygen saturation >90% had a higher mortality. Faster gait speed during the 6MWT was also associated with better survival.
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spelling pubmed-79058422021-02-25 Gait-speed and oxygen flow during six-minute walk test predicts mortality in patients with advanced lung disease Timofte, Irina Tonelli, Adriano Diaz-Abad, Montserrat Verceles, Avelino Ladikos, Nicholas Iacono, Aldo Terrin, Michael L. Wijesinha, Marniker Akindipe, Olufemi Baz, Maher Monaldi Arch Chest Dis Article The six-minute walk test (6MWT) is a useful tool to predict outcomes in patients with advanced lung diseases. Greater distance walked has been shown to have independent prognostic value. We reviewed the medical records of 164 patients with advanced lung disease who underwent lung transplant evaluation. Results of the 6MWT (distance walked, oxygen required to maintain oxygen saturation >90%, and gait speed) were recorded and analyzed with respect to mortality. 6MWT mean oxygen (O(2)) flow via nasal cannula was 3.5±3.7 1/min. The distance walked in meters (m) and percent predicted distance were inversely associated with mortality, hazard ratio (HR): 0.995 per meter (95% CI 0.992–0.998) for walk distance in meters and 0.970 per % predicted distance (95% CI 0.950–0.990). Patients who walked <200 meters [HR: 2.1 (95% CI 1.1–4.0)] or <45% of predicted, HR: 2.7 (95% CI 1.2–5.7) had higher mortality. O(2) flow during the test had a direct association with mortality (HR: 1.1 per L/min (95% CI 1.0–1.2). In multivariate analysis, O(2) flow >3.5 L/min remained predictive of mortality, HR: 1.1 per 1/min (95% CI 1.0–1.2). Gait speed was higher in patients who survived through follow-up compared to patients who died (mean 0.83±0.35 m/s vs 0.69±0.33 m/s, p=0.03). Gait speed >0.8 m/s was a predictor of survival, HR 3.4 (1.1, 10.6). In summary, distance walked and O(2) flow during the 6MWT were predictors of mortality in patients with advanced lung disease. Patients who required more than 3.5 1/m of O(2) to maintain oxygen saturation >90% had a higher mortality. Faster gait speed during the 6MWT was also associated with better survival. 2020-02-12 /pmc/articles/PMC7905842/ /pubmed/32072801 http://dx.doi.org/10.4081/monaldi.2020.1186 Text en http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Timofte, Irina
Tonelli, Adriano
Diaz-Abad, Montserrat
Verceles, Avelino
Ladikos, Nicholas
Iacono, Aldo
Terrin, Michael L.
Wijesinha, Marniker
Akindipe, Olufemi
Baz, Maher
Gait-speed and oxygen flow during six-minute walk test predicts mortality in patients with advanced lung disease
title Gait-speed and oxygen flow during six-minute walk test predicts mortality in patients with advanced lung disease
title_full Gait-speed and oxygen flow during six-minute walk test predicts mortality in patients with advanced lung disease
title_fullStr Gait-speed and oxygen flow during six-minute walk test predicts mortality in patients with advanced lung disease
title_full_unstemmed Gait-speed and oxygen flow during six-minute walk test predicts mortality in patients with advanced lung disease
title_short Gait-speed and oxygen flow during six-minute walk test predicts mortality in patients with advanced lung disease
title_sort gait-speed and oxygen flow during six-minute walk test predicts mortality in patients with advanced lung disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905842/
https://www.ncbi.nlm.nih.gov/pubmed/32072801
http://dx.doi.org/10.4081/monaldi.2020.1186
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