Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain

Pain is a common non-motor symptom of Parkinson’s disease (PD), with current limited knowledge of its pathophysiology. Here, we show that peripheral inoculation of mouse alpha-synuclein (α-Syn) pre-formed fibrils, in a transgenic mouse model of PD, elicited retrograde trans-synaptic spreading of α-S...

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Detalles Bibliográficos
Autores principales: Ferreira, Nelson, Gonçalves, Nádia Pereira, Jan, Asad, Jensen, Nanna Møller, van der Laan, Amelia, Mohseni, Simin, Vægter, Christian Bjerggaard, Jensen, Poul Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905893/
https://www.ncbi.nlm.nih.gov/pubmed/33632316
http://dx.doi.org/10.1186/s40478-021-01131-8

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