Cargando…

FK228 sensitizes radioresistant small cell lung cancer cells to radiation

BACKGROUND: Concurrent thoracic radiation plus chemotherapy is the mainstay of first-line treatment for limited-stage small cell lung cancer (LS-SCLC). Despite initial high responsiveness to combined chemo- and radiotherapy, SCLC almost invariably relapses and develops resistance within one year, le...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Hong, Ma, Liying, Bian, Xing, Lv, Yang, Lin, Wenchu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905898/ https://www.ncbi.nlm.nih.gov/pubmed/33632300 http://dx.doi.org/10.1186/s13148-021-01025-5

Ejemplares similares

FK228 from Burkholderia thailandensis MSMB43
por: Liu, Xiang-Yang, et al.
Publicado: (2012)

The dual HDAC-PI3K inhibitor CUDC-907 displays single-agent activity and synergizes with PARP inhibitor olaparib in small cell lung cancer
por: Ma, Liying, et al.
Publicado: (2020)

Correction to: The dual HDAC-PI3K inhibitor CUDC-907 displays single-agent activity and synergizes with PARP inhibitor olaparib in small cell lung cancer
por: Ma, Liying, et al.
Publicado: (2021)

FK228 Analogues Induce Fetal Hemoglobin in Human Erythroid Progenitors
por: Makala, Levi, et al.
Publicado: (2012)

The structural basis of an NADP(+)-independent dithiol oxidase in FK228 biosynthesis
por: Li, Jie, et al.
Publicado: (2014)

Apoptotic Cytotoxic Effects of a Histone Deacetylase Inhibitor, FK228, on Malignant Lymphoid Cells
por: Murata, Makoto, et al.
Publicado: (2000)

Mechanistic studies of DepR in regulating FK228 biosynthesis in Chromobacterium violaceum no. 968
por: Qiao, Yongjian, et al.
Publicado: (2018)

Genomics-guided discovery of a new and significantly better source of anticancer natural drug FK228
por: Liu, Xiangyang, et al.
Publicado: (2018)

The MYC Paralog-PARP1 Axis as a Potential Therapeutic Target in MYC Paralog-Activated Small Cell Lung Cancer
por: Bian, Xing, et al.
Publicado: (2020)

Treating Colon Cancer Cells with FK228 Reveals a Link between Histone Lysine Acetylation and Extensive Changes in the Cellular Proteome
por: Wang, Tian-yun, et al.
Publicado: (2015)

Combinatorial Antitumor Activity of Oxaliplatin with Epigenetic Modifying Agents, 5-Aza-CdR and FK228, in Human Gastric Cancer Cells
por: Park, Jong Kook, et al.
Publicado: (2018)

Corrigendum: The MYC paralog-PARP1 axis as a potential therapeutic target in MYC paralog-activated small cell lung cancer
por: Bian, Xing, et al.
Publicado: (2023)

Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer
por: Shi, Yehui, et al.
Publicado: (2020)

The HDAC Inhibitor FK228 Enhances Adenoviral Transgene Expression by a Transduction-Independent Mechanism but Does Not Increase Adenovirus Replication
por: Danielsson, Angelika, et al.
Publicado: (2011)

Biochemical, biological and structural properties of romidepsin (FK228) and its analogs as novel HDAC/PI3K dual inhibitors
por: Saijo, Ken, et al.
Publicado: (2015)

In vivo Effects of a Histone Deacetylase Inhibitor, FK228, on Human Acute Promyelocytic Leukemia in NOD/Shi‐scid/scid Mice
por: Kosugi, Hiroshi, et al.
Publicado: (2001)

Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibition
por: Gomez-Casal, Roberto, et al.
Publicado: (2015)

Role of FK506-sensitive signals in asthmatic lung inflammation
por: Tomiaki, Chihiro, et al.
Publicado: (2022)

Involvement of endothelial CK2 in the radiation induced perivascular resistant niche (PVRN) and the induction of radioresistance for non-small cell lung cancer (NSCLC) cells
por: Li, Qianwen, et al.
Publicado: (2019)

Targeting cancer stem cells by disulfiram and copper sensitizes radioresistant chondrosarcoma to radiation
por: Wang, Kun, et al.
Publicado: (2021)

Radioresistance of Non-Small Cell Lung Cancers and Therapeutic Perspectives
por: Césaire, Mathieu, et al.
Publicado: (2022)

Exosomal miR-92b-3p Promotes Chemoresistance of Small Cell Lung Cancer Through the PTEN/AKT Pathway
por: Li, Ming, et al.
Publicado: (2021)

Romidepsin (FK228) in a Mouse Model of Lipopolysaccharide-Induced Acute Kidney Injury is Associated with Down-Regulation of the CYP2E1 Gene
por: Cheng, Shulin, et al.
Publicado: (2020)

Investigation of Radiation-induced Transcriptome Profile of Radioresistant Non-small Cell Lung Cancer A549 Cells Using RNA-seq
por: Yang, Hee Jung, et al.
Publicado: (2013)

Review: Mechanisms and perspective treatment of radioresistance in non-small cell lung cancer
por: Zhou, Ting, et al.
Publicado: (2023)

The decay scheme of $^{228}$Fr and $K=0$ bands in $^{228}$Ra
por: Ruchowska, E, et al.
Publicado: (1982)

CircVAPA promotes small cell lung cancer progression by modulating the miR-377-3p and miR-494-3p/IGF1R/AKT axis
por: Hua, Jinghan, et al.
Publicado: (2022)

T228. SOCIAL REWARD REACTIVITY AND SENSITIVITY IN SCHIZOPHRENIA SPECTRUM CONDITIONS
por: Aldridge-Waddon, Luke, et al.
Publicado: (2020)

The NAMPT Inhibitor FK866 Increases Metformin Sensitivity in Pancreatic Cancer Cells
por: Parisotto, Maxime, et al.
Publicado: (2022)

Stathmin1 increases radioresistance by enhancing autophagy in non-small-cell lung cancer cells
por: Zhang, Xi, et al.
Publicado: (2016)

Ionizing radiation, ion transports, and radioresistance of cancer cells
por: Huber, Stephan M., et al.
Publicado: (2013)

Identification of Key Genes and FUNCTIONAL Pathway in Radioresistance of Non-Small Cell Lung Cancer
por: Li, Shouying, et al.
Publicado: (2022)

Transcriptome-Based Traits of Radioresistant Sublines of Non-Small Cell Lung Cancer Cells
por: Pustovalova, Margarita, et al.
Publicado: (2023)

BRD4 Targets the KEAP1-Nrf2-G6PD Axis and Suppresses Redox Metabolism in Small Cell Lung Cancer
por: Lv, Yang, et al.
Publicado: (2022)

Targeting DNA repair with PNKP inhibition sensitizes radioresistant prostate cancer cells to high LET radiation
por: Srivastava, Pallavi, et al.
Publicado: (2018)

The Molecular and Cellular Strategies of Glioblastoma and Non-Small-Cell Lung Cancer Cells Conferring Radioresistance
por: Alhaddad, Lina, et al.
Publicado: (2022)

Comprehensive analysis of the expression, prognosis, and immune infiltrates for CHDs in human lung cancer
por: Lv, Yang, et al.
Publicado: (2022)

Characterization and mechanisms of radioresistant lung squamous cell carcinoma cell lines
por: Pan, Lifang, et al.
Publicado: (2023)

Selection of Radioresistant Cells by Vitamin A Deficiency in a Small Cell Lung Cancer Cell Line
por: Terasaki, Takeo, et al.
Publicado: (1990)

A pancreatic ductal adenocarcinoma subpopulation is sensitive to FK866, an inhibitor of NAMPT
por: Barraud, Marine, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_1vqc0i04tta9cuf8qvnh6a6ubv