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Effect of stem cell treatment on functional recovery of spinocerebellar ataxia: systematic review and meta-analysis

BACKGROUND: Spinocerebellar ataxia is a hereditary neurodegenerative disease characterized by changes in balance, locomotion and motor coordination. Stem cell therapies are currently being investigated as an alternative to delay the evolution of the disease, and some experimental studies have invest...

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Autores principales: Appelt, Pablo Andrei, Comella, Kristin, de Souza, Luciane Aparecida Pascucci Sande, Luvizutto, Gustavo José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905903/
https://www.ncbi.nlm.nih.gov/pubmed/33632326
http://dx.doi.org/10.1186/s40673-021-00130-8
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author Appelt, Pablo Andrei
Comella, Kristin
de Souza, Luciane Aparecida Pascucci Sande
Luvizutto, Gustavo José
author_facet Appelt, Pablo Andrei
Comella, Kristin
de Souza, Luciane Aparecida Pascucci Sande
Luvizutto, Gustavo José
author_sort Appelt, Pablo Andrei
collection PubMed
description BACKGROUND: Spinocerebellar ataxia is a hereditary neurodegenerative disease characterized by changes in balance, locomotion and motor coordination. Stem cell therapies are currently being investigated as an alternative to delay the evolution of the disease, and some experimental studies have investigated the effect of stem cell treatment on spinocerebellar ataxia. OBJECTIVES: The aim of this review was to investigate whether the application of stem cells produced an effect on functional recovery in individuals with spinocerebellar ataxia. METHODS: The studies included in this review investigated the efficacy and safety of a protocol for the application of mesenchymal stem cells extracted from umbilical cord and adipose tissue. Two studies used intrathecal route for application and one study used intravenous route. RESULTS: Studies have shown clinical improvement in the scores of the ICARS (International Cooperative Ataxia Rating Scale), ADL (Activities of Daily Living Scale), BBS (Berg Balance Scale) and SARA (Scale for the Assessment and Rating of Ataxia), but lacked statistical significance. CONCLUSIONS: There was low evidence for recommending stem cell therapy in individuals with spinocerebellar ataxia, and no statistical difference was observed for improving functional recovery of patients. Further studies are needed with different designs, largest sample sizes and placebo control, to fully understand anticipated outcomes of cellular therapy for spinocerebellar ataxia.
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spelling pubmed-79059032021-02-25 Effect of stem cell treatment on functional recovery of spinocerebellar ataxia: systematic review and meta-analysis Appelt, Pablo Andrei Comella, Kristin de Souza, Luciane Aparecida Pascucci Sande Luvizutto, Gustavo José Cerebellum Ataxias Review BACKGROUND: Spinocerebellar ataxia is a hereditary neurodegenerative disease characterized by changes in balance, locomotion and motor coordination. Stem cell therapies are currently being investigated as an alternative to delay the evolution of the disease, and some experimental studies have investigated the effect of stem cell treatment on spinocerebellar ataxia. OBJECTIVES: The aim of this review was to investigate whether the application of stem cells produced an effect on functional recovery in individuals with spinocerebellar ataxia. METHODS: The studies included in this review investigated the efficacy and safety of a protocol for the application of mesenchymal stem cells extracted from umbilical cord and adipose tissue. Two studies used intrathecal route for application and one study used intravenous route. RESULTS: Studies have shown clinical improvement in the scores of the ICARS (International Cooperative Ataxia Rating Scale), ADL (Activities of Daily Living Scale), BBS (Berg Balance Scale) and SARA (Scale for the Assessment and Rating of Ataxia), but lacked statistical significance. CONCLUSIONS: There was low evidence for recommending stem cell therapy in individuals with spinocerebellar ataxia, and no statistical difference was observed for improving functional recovery of patients. Further studies are needed with different designs, largest sample sizes and placebo control, to fully understand anticipated outcomes of cellular therapy for spinocerebellar ataxia. BioMed Central 2021-02-25 /pmc/articles/PMC7905903/ /pubmed/33632326 http://dx.doi.org/10.1186/s40673-021-00130-8 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Appelt, Pablo Andrei
Comella, Kristin
de Souza, Luciane Aparecida Pascucci Sande
Luvizutto, Gustavo José
Effect of stem cell treatment on functional recovery of spinocerebellar ataxia: systematic review and meta-analysis
title Effect of stem cell treatment on functional recovery of spinocerebellar ataxia: systematic review and meta-analysis
title_full Effect of stem cell treatment on functional recovery of spinocerebellar ataxia: systematic review and meta-analysis
title_fullStr Effect of stem cell treatment on functional recovery of spinocerebellar ataxia: systematic review and meta-analysis
title_full_unstemmed Effect of stem cell treatment on functional recovery of spinocerebellar ataxia: systematic review and meta-analysis
title_short Effect of stem cell treatment on functional recovery of spinocerebellar ataxia: systematic review and meta-analysis
title_sort effect of stem cell treatment on functional recovery of spinocerebellar ataxia: systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905903/
https://www.ncbi.nlm.nih.gov/pubmed/33632326
http://dx.doi.org/10.1186/s40673-021-00130-8
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