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CENP-A overexpression promotes aneuploidy with karyotypic heterogeneity

Chromosomal instability (CIN) is a hallmark of many cancers. Restricting the localization of centromeric histone H3 variant CENP-A to centromeres prevents CIN. CENP-A overexpression (OE) and mislocalization have been observed in cancers and correlate with poor prognosis; however, the molecular conse...

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Detalles Bibliográficos
Autores principales:	Shrestha, Roshan L., Rossi, Austin, Wangsa, Darawalee, Hogan, Ann K., Zaldana, Kimberly S., Suva, Evelyn, Chung, Yang Jo, Sanders, Chelsea L., Difilippantonio, Simone, Karpova, Tatiana S., Karim, Baktiar, Foltz, Daniel R., Fachinetti, Daniele, Aplan, Peter D., Ried, Thomas, Basrai, Munira A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905998/ https://www.ncbi.nlm.nih.gov/pubmed/33620383 http://dx.doi.org/10.1083/jcb.202007195

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