Cargando…

Radiofrequency Ablation of Parathyroid Adenomas: Safety and Efficacy in a Study of 10 Patients

PURPOSE: To evaluate safety and effectiveness of ultrasound-guided percutaneous radiofrequency ablation of parathyroid adenoma in surgically unfit patients with hypercalcemia because of hyperparathyroidism. MATERIALS AND METHODS: A retrospective review of hospital records from Jan 2012 to Dec 2018 r...

Descripción completa

Detalles Bibliográficos
Autores principales: Khandelwal, Anubhav Harish, Batra, Smarth, Jajodia, Surabhi, Gupta, Saurabh, Khandelwal, Rohit, Kapoor, Abhay Kumar, Mishra, Sunil Kumar, Baijal, S. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906106/
https://www.ncbi.nlm.nih.gov/pubmed/33643872
http://dx.doi.org/10.4103/ijem.IJEM_671_20
_version_ 1783655227630551040
author Khandelwal, Anubhav Harish
Batra, Smarth
Jajodia, Surabhi
Gupta, Saurabh
Khandelwal, Rohit
Kapoor, Abhay Kumar
Mishra, Sunil Kumar
Baijal, S. S.
author_facet Khandelwal, Anubhav Harish
Batra, Smarth
Jajodia, Surabhi
Gupta, Saurabh
Khandelwal, Rohit
Kapoor, Abhay Kumar
Mishra, Sunil Kumar
Baijal, S. S.
author_sort Khandelwal, Anubhav Harish
collection PubMed
description PURPOSE: To evaluate safety and effectiveness of ultrasound-guided percutaneous radiofrequency ablation of parathyroid adenoma in surgically unfit patients with hypercalcemia because of hyperparathyroidism. MATERIALS AND METHODS: A retrospective review of hospital records from Jan 2012 to Dec 2018 revealed 10 patients, who had undergone ablation for solitary parathyroid adenoma. All 10 patients suffered from hyperparathyroidism because of parathyroid adenoma, resulting in hypercalcemia. These patients were surgically unfit because of comorbidities. Pre-ablation serum calcium and serum parathormone levels were measured and compared with the levels after the ablation. RESULTS: Mean serum calcium level decreased significantly from 2.81 ± 0.17 mmol/L pre-ablation to 2.42 ± 0.17 mmol/L 72 h after ablation and parathyroid hormone levels became normal in all patients within 7 days. Seven patients remained normo-calcaemic at 6 months follow-up with no signs and symptoms of hyperparathyroidism. One patient with pancreatitis died after 15 days because of pre-existing multi-organ failure. Two patients were lost to follow-up before 6 months. CONCLUSION: Radiofrequency ablation of parathyroid adenoma is a safe and effective alternate treatment method for symptomatic hypercalcemia in surgically unfit patients suffering from primary hyperparathyroidism because of parathyroid adenoma.
format Online
Article
Text
id pubmed-7906106
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-79061062021-02-26 Radiofrequency Ablation of Parathyroid Adenomas: Safety and Efficacy in a Study of 10 Patients Khandelwal, Anubhav Harish Batra, Smarth Jajodia, Surabhi Gupta, Saurabh Khandelwal, Rohit Kapoor, Abhay Kumar Mishra, Sunil Kumar Baijal, S. S. Indian J Endocrinol Metab Original Article PURPOSE: To evaluate safety and effectiveness of ultrasound-guided percutaneous radiofrequency ablation of parathyroid adenoma in surgically unfit patients with hypercalcemia because of hyperparathyroidism. MATERIALS AND METHODS: A retrospective review of hospital records from Jan 2012 to Dec 2018 revealed 10 patients, who had undergone ablation for solitary parathyroid adenoma. All 10 patients suffered from hyperparathyroidism because of parathyroid adenoma, resulting in hypercalcemia. These patients were surgically unfit because of comorbidities. Pre-ablation serum calcium and serum parathormone levels were measured and compared with the levels after the ablation. RESULTS: Mean serum calcium level decreased significantly from 2.81 ± 0.17 mmol/L pre-ablation to 2.42 ± 0.17 mmol/L 72 h after ablation and parathyroid hormone levels became normal in all patients within 7 days. Seven patients remained normo-calcaemic at 6 months follow-up with no signs and symptoms of hyperparathyroidism. One patient with pancreatitis died after 15 days because of pre-existing multi-organ failure. Two patients were lost to follow-up before 6 months. CONCLUSION: Radiofrequency ablation of parathyroid adenoma is a safe and effective alternate treatment method for symptomatic hypercalcemia in surgically unfit patients suffering from primary hyperparathyroidism because of parathyroid adenoma. Wolters Kluwer - Medknow 2020 2021-01-12 /pmc/articles/PMC7906106/ /pubmed/33643872 http://dx.doi.org/10.4103/ijem.IJEM_671_20 Text en Copyright: © 2021 Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Khandelwal, Anubhav Harish
Batra, Smarth
Jajodia, Surabhi
Gupta, Saurabh
Khandelwal, Rohit
Kapoor, Abhay Kumar
Mishra, Sunil Kumar
Baijal, S. S.
Radiofrequency Ablation of Parathyroid Adenomas: Safety and Efficacy in a Study of 10 Patients
title Radiofrequency Ablation of Parathyroid Adenomas: Safety and Efficacy in a Study of 10 Patients
title_full Radiofrequency Ablation of Parathyroid Adenomas: Safety and Efficacy in a Study of 10 Patients
title_fullStr Radiofrequency Ablation of Parathyroid Adenomas: Safety and Efficacy in a Study of 10 Patients
title_full_unstemmed Radiofrequency Ablation of Parathyroid Adenomas: Safety and Efficacy in a Study of 10 Patients
title_short Radiofrequency Ablation of Parathyroid Adenomas: Safety and Efficacy in a Study of 10 Patients
title_sort radiofrequency ablation of parathyroid adenomas: safety and efficacy in a study of 10 patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906106/
https://www.ncbi.nlm.nih.gov/pubmed/33643872
http://dx.doi.org/10.4103/ijem.IJEM_671_20
work_keys_str_mv AT khandelwalanubhavharish radiofrequencyablationofparathyroidadenomassafetyandefficacyinastudyof10patients
AT batrasmarth radiofrequencyablationofparathyroidadenomassafetyandefficacyinastudyof10patients
AT jajodiasurabhi radiofrequencyablationofparathyroidadenomassafetyandefficacyinastudyof10patients
AT guptasaurabh radiofrequencyablationofparathyroidadenomassafetyandefficacyinastudyof10patients
AT khandelwalrohit radiofrequencyablationofparathyroidadenomassafetyandefficacyinastudyof10patients
AT kapoorabhaykumar radiofrequencyablationofparathyroidadenomassafetyandefficacyinastudyof10patients
AT mishrasunilkumar radiofrequencyablationofparathyroidadenomassafetyandefficacyinastudyof10patients
AT baijalss radiofrequencyablationofparathyroidadenomassafetyandefficacyinastudyof10patients