Cargando…
DNA- and telomere-damage does not limit lifespan: evidence from rapamycin
Failure of rapamycin to extend lifespan in DNA repair mutant and telomerase-knockout mice, while extending lifespan in normal mice, indicates that neither DNA damage nor telomere shortening limits normal lifespan or causes normal aging.
| Autor principal: | |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906135/ https://www.ncbi.nlm.nih.gov/pubmed/33578394 http://dx.doi.org/10.18632/aging.202674 |
| _version_ | 1783655230741676032 |
|---|---|
| author | Blagosklonny, Mikhail V. |
| author_facet | Blagosklonny, Mikhail V. |
| author_sort | Blagosklonny, Mikhail V. |
| collection | PubMed |
| description | Failure of rapamycin to extend lifespan in DNA repair mutant and telomerase-knockout mice, while extending lifespan in normal mice, indicates that neither DNA damage nor telomere shortening limits normal lifespan or causes normal aging. |
| format | Online Article Text |
| id | pubmed-7906135 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Impact Journals |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-79061352021-03-04 DNA- and telomere-damage does not limit lifespan: evidence from rapamycin Blagosklonny, Mikhail V. Aging (Albany NY) Research Perspective Failure of rapamycin to extend lifespan in DNA repair mutant and telomerase-knockout mice, while extending lifespan in normal mice, indicates that neither DNA damage nor telomere shortening limits normal lifespan or causes normal aging. Impact Journals 2021-02-12 /pmc/articles/PMC7906135/ /pubmed/33578394 http://dx.doi.org/10.18632/aging.202674 Text en Copyright: © 2021 Blagosklonny. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| spellingShingle | Research Perspective Blagosklonny, Mikhail V. DNA- and telomere-damage does not limit lifespan: evidence from rapamycin |
| title | DNA- and telomere-damage does not limit lifespan: evidence from rapamycin |
| title_full | DNA- and telomere-damage does not limit lifespan: evidence from rapamycin |
| title_fullStr | DNA- and telomere-damage does not limit lifespan: evidence from rapamycin |
| title_full_unstemmed | DNA- and telomere-damage does not limit lifespan: evidence from rapamycin |
| title_short | DNA- and telomere-damage does not limit lifespan: evidence from rapamycin |
| title_sort | dna- and telomere-damage does not limit lifespan: evidence from rapamycin |
| topic | Research Perspective |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906135/ https://www.ncbi.nlm.nih.gov/pubmed/33578394 http://dx.doi.org/10.18632/aging.202674 |
| work_keys_str_mv | AT blagosklonnymikhailv dnaandtelomeredamagedoesnotlimitlifespanevidencefromrapamycin |