Polyglutamine-expanded ataxin3 alter specific gene expressions through changing DNA methylation status in SCA3/MJD

DNA methylation has recently been linked to transcriptional dysregulation and neuronal dysfunction in polyglutamine (polyQ) disease. This study aims to determine whether (CAG)(n) expansion in ATXN3 perturbs DNA methylation status and affects gene expression. We analyzed DNA methylation throughout th...

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Detalles Bibliográficos
Autores principales: Ding, Dongxue, Wang, Chunrong, Chen, Zhao, Xia, Kun, Tang, Beisha, Qiu, Rong, Jiang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906150/
https://www.ncbi.nlm.nih.gov/pubmed/33411688
http://dx.doi.org/10.18632/aging.202331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906150/
https://www.ncbi.nlm.nih.gov/pubmed/33411688
http://dx.doi.org/10.18632/aging.202331

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