Cargando…
Identification of HIPK3 as a potential biomarker and an inhibitor of clear cell renal cell carcinoma
Invasion and metastasis are the main causes of poor prognosis in patients with clear cell renal cell carcinoma (ccRCC). The homeodomain interacting protein kinases (HIPKs) can regulate cell proliferation and apoptosis. Little is known about the prognostic role of HIPKs in ccRCC. Here we use Kaplan-M...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906163/ https://www.ncbi.nlm.nih.gov/pubmed/33495417 http://dx.doi.org/10.18632/aging.202294 |
_version_ | 1783655237438930944 |
---|---|
author | Xiao, Wen Wang, Tao Ye, Yuzhong Wang, Xuegang Chen, Bin Xing, Jinchun Yang, Hongmei Zhang, Xiaoping |
author_facet | Xiao, Wen Wang, Tao Ye, Yuzhong Wang, Xuegang Chen, Bin Xing, Jinchun Yang, Hongmei Zhang, Xiaoping |
author_sort | Xiao, Wen |
collection | PubMed |
description | Invasion and metastasis are the main causes of poor prognosis in patients with clear cell renal cell carcinoma (ccRCC). The homeodomain interacting protein kinases (HIPKs) can regulate cell proliferation and apoptosis. Little is known about the prognostic role of HIPKs in ccRCC. Here we use Kaplan-Meier survival analysis and multivariate analysis to analyze the correlation of overall survival (OS) and disease–free survival (DFS). ROC curves analyzed the relationship between clinicopathological parameters and HIPK3 expression in ccRCC. Univariate analysis and multivariate analysis confirmed that the expression of HIPK3 was associated with OS (HR, 0.701; P=0.041) and DFS (HR, 0.630; P=0.012). Low HIPK3 expression was a poor prognostic factor and HIPK3 expression was significantly down-regulated in ccRCC cancer tissues when compared with normal renal tissues. In vitro cell results also confirmed that HIPK3 over-expression could inhibit tumor growth and malignant characteristics. The results indicate that low expression of HIPK3 in ccRCC tissues is significantly associated with poor survival rates in tumor patients, and HIPK3 may be used as a valuable biomarker and inhibitor of ccRCC. |
format | Online Article Text |
id | pubmed-7906163 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-79061632021-03-04 Identification of HIPK3 as a potential biomarker and an inhibitor of clear cell renal cell carcinoma Xiao, Wen Wang, Tao Ye, Yuzhong Wang, Xuegang Chen, Bin Xing, Jinchun Yang, Hongmei Zhang, Xiaoping Aging (Albany NY) Research Paper Invasion and metastasis are the main causes of poor prognosis in patients with clear cell renal cell carcinoma (ccRCC). The homeodomain interacting protein kinases (HIPKs) can regulate cell proliferation and apoptosis. Little is known about the prognostic role of HIPKs in ccRCC. Here we use Kaplan-Meier survival analysis and multivariate analysis to analyze the correlation of overall survival (OS) and disease–free survival (DFS). ROC curves analyzed the relationship between clinicopathological parameters and HIPK3 expression in ccRCC. Univariate analysis and multivariate analysis confirmed that the expression of HIPK3 was associated with OS (HR, 0.701; P=0.041) and DFS (HR, 0.630; P=0.012). Low HIPK3 expression was a poor prognostic factor and HIPK3 expression was significantly down-regulated in ccRCC cancer tissues when compared with normal renal tissues. In vitro cell results also confirmed that HIPK3 over-expression could inhibit tumor growth and malignant characteristics. The results indicate that low expression of HIPK3 in ccRCC tissues is significantly associated with poor survival rates in tumor patients, and HIPK3 may be used as a valuable biomarker and inhibitor of ccRCC. Impact Journals 2021-01-20 /pmc/articles/PMC7906163/ /pubmed/33495417 http://dx.doi.org/10.18632/aging.202294 Text en Copyright: © 2021 Xiao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Xiao, Wen Wang, Tao Ye, Yuzhong Wang, Xuegang Chen, Bin Xing, Jinchun Yang, Hongmei Zhang, Xiaoping Identification of HIPK3 as a potential biomarker and an inhibitor of clear cell renal cell carcinoma |
title | Identification of HIPK3 as a potential biomarker and an inhibitor of clear cell renal cell carcinoma |
title_full | Identification of HIPK3 as a potential biomarker and an inhibitor of clear cell renal cell carcinoma |
title_fullStr | Identification of HIPK3 as a potential biomarker and an inhibitor of clear cell renal cell carcinoma |
title_full_unstemmed | Identification of HIPK3 as a potential biomarker and an inhibitor of clear cell renal cell carcinoma |
title_short | Identification of HIPK3 as a potential biomarker and an inhibitor of clear cell renal cell carcinoma |
title_sort | identification of hipk3 as a potential biomarker and an inhibitor of clear cell renal cell carcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906163/ https://www.ncbi.nlm.nih.gov/pubmed/33495417 http://dx.doi.org/10.18632/aging.202294 |
work_keys_str_mv | AT xiaowen identificationofhipk3asapotentialbiomarkerandaninhibitorofclearcellrenalcellcarcinoma AT wangtao identificationofhipk3asapotentialbiomarkerandaninhibitorofclearcellrenalcellcarcinoma AT yeyuzhong identificationofhipk3asapotentialbiomarkerandaninhibitorofclearcellrenalcellcarcinoma AT wangxuegang identificationofhipk3asapotentialbiomarkerandaninhibitorofclearcellrenalcellcarcinoma AT chenbin identificationofhipk3asapotentialbiomarkerandaninhibitorofclearcellrenalcellcarcinoma AT xingjinchun identificationofhipk3asapotentialbiomarkerandaninhibitorofclearcellrenalcellcarcinoma AT yanghongmei identificationofhipk3asapotentialbiomarkerandaninhibitorofclearcellrenalcellcarcinoma AT zhangxiaoping identificationofhipk3asapotentialbiomarkerandaninhibitorofclearcellrenalcellcarcinoma |