Cargando…

LNK promotes granulosa cell apoptosis in PCOS via negatively regulating insulin-stimulated AKT-FOXO3 pathway

Background: Polycystic ovary syndrome (PCOS), which is often accompanied by insulin resistance, is closely related to increased apoptosis of ovarian granulosa cells. LNK is an important regulator of the insulin signaling pathway. When insulin binds to the receptor, the PI3K/AKT/FOXO signaling pathwa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tan, Min, Cheng, Yanxiang, Zhong, Xiaozhu, Yang, Dongyong, Jiang, Sushi, Ye, Yang, Ding, Miao, Guan, Guijun, Yang, Dongzi, Zhao, Xiaomiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906173/ https://www.ncbi.nlm.nih.gov/pubmed/33495419 http://dx.doi.org/10.18632/aging.202421

Ejemplares similares

The Degree of Menstrual Disturbance Is Associated With the Severity of Insulin Resistance in PCOS
por: Li, Xiaojia, et al.
Publicado: (2022)

LNK deficiency decreases obesity-induced insulin resistance by regulating GLUT4 through the PI3K-Akt-AS160 pathway in adipose tissue
por: Zhong, Xiaozhu, et al.
Publicado: (2020)

Gut Microbiota Dysbiosis Ameliorates in LNK-Deficient Mouse Models with Obesity-Induced Insulin Resistance Improvement
por: Chen, Jingbo, et al.
Publicado: (2023)

MiR-93-5p promotes granulosa cell apoptosis and ferroptosis by the NF-kB signaling pathway in polycystic ovary syndrome
por: Tan, Wei, et al.
Publicado: (2022)

Silencing of lncRNA UCA1 inhibited the pathological progression in PCOS mice through the regulation of PI3K/AKT signaling pathway
por: Yang, Dongyong, et al.
Publicado: (2021)

LNK suppresses interferon signaling in melanoma
por: Ding, Ling-Wen, et al.
Publicado: (2019)

Environmental Pollutant Benzo[a]pyrene Induces Recurrent Pregnancy Loss through Promoting Apoptosis and Suppressing Migration of Extravillous Trophoblast
por: Ye, Yang, et al.
Publicado: (2020)

FOXO3 Is Expressed in Ovarian Tissues and Acts as an Apoptosis Initiator in Granulosa Cells of Chickens
por: Cui, Can, et al.
Publicado: (2019)

Immunity and coagulation and fibrinolytic processes may reduce the risk of severe illness in pregnant women with coronavirus disease 2019
por: Zhong, Yajuan, et al.
Publicado: (2021)

Irisin reduces the abnormal reproductive and metabolic phenotypes of PCOS by regulating the activity of brown adipose tissue in mice(†)
por: Zheng, Yajing, et al.
Publicado: (2022)

Non-Esterified Fatty Acid-Induced Apoptosis in Bovine Granulosa Cells via ROS-Activated PI3K/AKT/FoxO1 Pathway
por: Lei, Zhiqi, et al.
Publicado: (2023)

The role of FDX1 in granulosa cell of Polycystic ovary syndrome (PCOS)
por: Wang, Zhi, et al.
Publicado: (2021)

Decreased Expression of Sam68 Is Associated with Insulin Resistance in Granulosa Cells from PCOS Patients
por: Vilariño-García, Teresa, et al.
Publicado: (2022)

SRSFs mediate the function of AR in the ovarian granulosa cells of patients with PCOS
por: Luo, Jing, et al.
Publicado: (2019)

The Polymorphisms in LNK Gene Correlated to the Clinical Type of Myeloproliferative Neoplasms
por: Chen, Yan, et al.
Publicado: (2016)

COLD REGULATED GENE 27 and 28 antagonize the transcriptional activity of the RVE8/LNK1/LNK2 circadian complex
por: Sorkin, Maria L, et al.
Publicado: (2023)

miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation
por: Zhang, Mei, et al.
Publicado: (2017)

Resveratrol regulates insulin resistance to improve the glycolytic pathway by activating SIRT2 in PCOS granulosa cells
por: Liang, Aihong, et al.
Publicado: (2023)

Neuropeptide Y directly reduced apoptosis of granulosa cells, and the expression of NPY and its receptors in PCOS subjects
por: Urata, Yoko, et al.
Publicado: (2023)

LNK (SH2B3): paradoxical effects in ovarian cancer
por: Ding, Ling-Wen, et al.
Publicado: (2014)

Melatonin enhances SIRT1 to ameliorate mitochondrial membrane damage by activating PDK1/Akt in granulosa cells of PCOS
por: Zheng, Bo, et al.
Publicado: (2021)

Expression Level of ADAMTS1 in Granulosa Cells of PCOS Patients Is Related to Granulosa Cell Function, Oocyte Quality, and Embryo Development
por: Yang, Guang, et al.
Publicado: (2021)

The Drosophila SH2B Family Adaptor Lnk Acts in Parallel to Chico in the Insulin Signaling Pathway
por: Werz, Christian, et al.
Publicado: (2009)

Up-regulation of miR-133a-3p promotes ovary insulin resistance on granulosa cells of obese PCOS patients via inhibiting PI3K/AKT signaling
por: Yang, Xiaoman, et al.
Publicado: (2022)

Lnk is an important modulator of insulin-like growth factor-1/Akt/peroxisome proliferator-activated receptor-gamma axis during adipogenesis of mesenchymal stem cells
por: Lee, Jun Hee, et al.
Publicado: (2016)

Spexin role in human granulosa cells physiology and PCOS: expression and negative impact on steroidogenesis and proliferation
por: Kurowska, Patrycja, et al.
Publicado: (2023)

Lnk Inhibits Tpo–mpl Signaling and Tpo-mediated Megakaryocytopoiesis
por: Tong, Wei, et al.
Publicado: (2004)

Cytokine Signaling and Hematopoietic Homeostasis Are Disrupted in Lnk-deficient Mice
por: Velazquez, Laura, et al.
Publicado: (2002)

ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats
por: Zheng, Qin, et al.
Publicado: (2017)

Involvement of FoxO1 in the effects of follicle-stimulating hormone on inhibition of apoptosis in mouse granulosa cells
por: Shen, M, et al.
Publicado: (2014)

Melatonin-Mediated Suppression of mtROS-JNK-FOXO1 Pathway Alleviates Hypoxia-Induced Apoptosis in Porcine Granulosa Cells
por: Zhang, Xuan, et al.
Publicado: (2023)

The Lnk/SH2B adaptor provides a fail-safe mechanism to establish the Insulin receptor-Chico interaction
por: Almudi, Isabel, et al.
Publicado: (2013)

The LNK Gene Family: At the Crossroad between Light Signaling and the Circadian Clock
por: de Leone, María José, et al.
Publicado: (2018)

Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK
por: Morris, Rhiannon, et al.
Publicado: (2021)

MON-201 ER Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS
por: Azhary, Jerilee, et al.
Publicado: (2019)

Is a GnRH Antagonist Protocol Better in PCOS Patients? A Meta-Analysis of RCTs
por: Lin, Haiyan, et al.
Publicado: (2014)

Oxidative Stress Induces Mouse Follicular Granulosa Cells Apoptosis via JNK/FoxO1 Pathway
por: Weng, Qiannan, et al.
Publicado: (2016)

Lnk-dependent axis of SCF–cKit signal for osteogenesis in bone fracture healing
por: Matsumoto, Tomoyuki, et al.
Publicado: (2010)

Identification of Polycystic Ovary Syndrome (PCOS) Specific Genes in Cumulus and Mural Granulosa Cells
por: Aydos, Alp, et al.
Publicado: (2016)

Reduced Endothelin-2 and Hypoxic Signaling Pathways in Granulosa-Lutein Cells of PCOS Women
por: Szymanska, Magdalena, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_k8kv52g50uu34fd9e35gfdlrar