LncRNA XIST sponges miR-199a-3p to modulate the Sp1/LRRK2 signal pathway to accelerate Parkinson’s disease progression

In vitro and in vivo models of Parkinson’s disease were established to investigate the effects of the lncRNA XIST/miR-199a-3p/Sp1/LRRK2 axis. The binding between XIST and miR-199a-3p as well as miR-199a-3p and Sp1 were examined by luciferase reporter assay and confirmed by RNA immunoprecipitation an...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Qian, Zhang, Ming-Ming, Liu, Min, Tan, Zhi-Gang, Qin, Qi-Lin, Jiang, Yu-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906184/
https://www.ncbi.nlm.nih.gov/pubmed/33494069
http://dx.doi.org/10.18632/aging.202378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906184/
https://www.ncbi.nlm.nih.gov/pubmed/33494069
http://dx.doi.org/10.18632/aging.202378

Ejemplares similares