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Suppression of p16 alleviates the senescence-associated secretory phenotype

Oncogene-induced senescence (OIS) is characterized by increased expression of the cell cycle inhibitor p16, leading to a hallmark cell cycle arrest. Suppression of p16 in this context drives proliferation, senescence bypass, and contributes to tumorigenesis. OIS cells are also characterized by the e...

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Detalles Bibliográficos
Autores principales:	Buj, Raquel, Leon, Kelly E., Anguelov, Marlyn A., Aird, Katherine M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906185/ https://www.ncbi.nlm.nih.gov/pubmed/33550279 http://dx.doi.org/10.18632/aging.202640

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