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Estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside
There are rarely systematic studies to analyze the prognostic factors among non-surgical liver cancer patients. Whether there is a gender difference in the survival of non-surgical liver cancer patients and what may cause this difference is still unclear. A total of 12,312 non-surgical liver cancer...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906196/ https://www.ncbi.nlm.nih.gov/pubmed/33428602 http://dx.doi.org/10.18632/aging.202280 |
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author | Wang, Rangrang Liu, Yuan Sun, Hongze Wang, Tao Li, Changcan Fan, Junwei Wang, Zhaowen |
author_facet | Wang, Rangrang Liu, Yuan Sun, Hongze Wang, Tao Li, Changcan Fan, Junwei Wang, Zhaowen |
author_sort | Wang, Rangrang |
collection | PubMed |
description | There are rarely systematic studies to analyze the prognostic factors among non-surgical liver cancer patients. Whether there is a gender difference in the survival of non-surgical liver cancer patients and what may cause this difference is still unclear. A total of 12,312 non-surgical liver cancer patients were enrolled in this study. Age, race, sex, grade, tumor TNM stage, marital status, tumor size, and histological type were independent risk factors in liver cancer and were confirmed in the validation cohort. Before menopause, females demonstrated a better mean survival probability than males (39.4±1.4 vs. 32.7±0.8 months, respectively; p<0.001), and continued in post-menopause. The results of differentially expressed genes (DEGs) and KEGG pathway analysis showed that there were significant differences in steroid hormone biosynthesis between male and female liver cancer patients. In vitro experiments revealed that estradiol inhibited the proliferation of hepatocellular cancer cell lines and increased apoptosis, but estrone exerted no effect. In conclusion, gender differences in prognosis among non-surgical liver cancer patients were confirmed and attributable primarily to estradiol. |
format | Online Article Text |
id | pubmed-7906196 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-79061962021-03-04 Estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside Wang, Rangrang Liu, Yuan Sun, Hongze Wang, Tao Li, Changcan Fan, Junwei Wang, Zhaowen Aging (Albany NY) Research Paper There are rarely systematic studies to analyze the prognostic factors among non-surgical liver cancer patients. Whether there is a gender difference in the survival of non-surgical liver cancer patients and what may cause this difference is still unclear. A total of 12,312 non-surgical liver cancer patients were enrolled in this study. Age, race, sex, grade, tumor TNM stage, marital status, tumor size, and histological type were independent risk factors in liver cancer and were confirmed in the validation cohort. Before menopause, females demonstrated a better mean survival probability than males (39.4±1.4 vs. 32.7±0.8 months, respectively; p<0.001), and continued in post-menopause. The results of differentially expressed genes (DEGs) and KEGG pathway analysis showed that there were significant differences in steroid hormone biosynthesis between male and female liver cancer patients. In vitro experiments revealed that estradiol inhibited the proliferation of hepatocellular cancer cell lines and increased apoptosis, but estrone exerted no effect. In conclusion, gender differences in prognosis among non-surgical liver cancer patients were confirmed and attributable primarily to estradiol. Impact Journals 2021-01-10 /pmc/articles/PMC7906196/ /pubmed/33428602 http://dx.doi.org/10.18632/aging.202280 Text en Copyright: © 2021 Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Wang, Rangrang Liu, Yuan Sun, Hongze Wang, Tao Li, Changcan Fan, Junwei Wang, Zhaowen Estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside |
title | Estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside |
title_full | Estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside |
title_fullStr | Estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside |
title_full_unstemmed | Estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside |
title_short | Estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside |
title_sort | estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906196/ https://www.ncbi.nlm.nih.gov/pubmed/33428602 http://dx.doi.org/10.18632/aging.202280 |
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