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Estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside

There are rarely systematic studies to analyze the prognostic factors among non-surgical liver cancer patients. Whether there is a gender difference in the survival of non-surgical liver cancer patients and what may cause this difference is still unclear. A total of 12,312 non-surgical liver cancer...

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Autores principales: Wang, Rangrang, Liu, Yuan, Sun, Hongze, Wang, Tao, Li, Changcan, Fan, Junwei, Wang, Zhaowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906196/
https://www.ncbi.nlm.nih.gov/pubmed/33428602
http://dx.doi.org/10.18632/aging.202280
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author Wang, Rangrang
Liu, Yuan
Sun, Hongze
Wang, Tao
Li, Changcan
Fan, Junwei
Wang, Zhaowen
author_facet Wang, Rangrang
Liu, Yuan
Sun, Hongze
Wang, Tao
Li, Changcan
Fan, Junwei
Wang, Zhaowen
author_sort Wang, Rangrang
collection PubMed
description There are rarely systematic studies to analyze the prognostic factors among non-surgical liver cancer patients. Whether there is a gender difference in the survival of non-surgical liver cancer patients and what may cause this difference is still unclear. A total of 12,312 non-surgical liver cancer patients were enrolled in this study. Age, race, sex, grade, tumor TNM stage, marital status, tumor size, and histological type were independent risk factors in liver cancer and were confirmed in the validation cohort. Before menopause, females demonstrated a better mean survival probability than males (39.4±1.4 vs. 32.7±0.8 months, respectively; p<0.001), and continued in post-menopause. The results of differentially expressed genes (DEGs) and KEGG pathway analysis showed that there were significant differences in steroid hormone biosynthesis between male and female liver cancer patients. In vitro experiments revealed that estradiol inhibited the proliferation of hepatocellular cancer cell lines and increased apoptosis, but estrone exerted no effect. In conclusion, gender differences in prognosis among non-surgical liver cancer patients were confirmed and attributable primarily to estradiol.
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spelling pubmed-79061962021-03-04 Estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside Wang, Rangrang Liu, Yuan Sun, Hongze Wang, Tao Li, Changcan Fan, Junwei Wang, Zhaowen Aging (Albany NY) Research Paper There are rarely systematic studies to analyze the prognostic factors among non-surgical liver cancer patients. Whether there is a gender difference in the survival of non-surgical liver cancer patients and what may cause this difference is still unclear. A total of 12,312 non-surgical liver cancer patients were enrolled in this study. Age, race, sex, grade, tumor TNM stage, marital status, tumor size, and histological type were independent risk factors in liver cancer and were confirmed in the validation cohort. Before menopause, females demonstrated a better mean survival probability than males (39.4±1.4 vs. 32.7±0.8 months, respectively; p<0.001), and continued in post-menopause. The results of differentially expressed genes (DEGs) and KEGG pathway analysis showed that there were significant differences in steroid hormone biosynthesis between male and female liver cancer patients. In vitro experiments revealed that estradiol inhibited the proliferation of hepatocellular cancer cell lines and increased apoptosis, but estrone exerted no effect. In conclusion, gender differences in prognosis among non-surgical liver cancer patients were confirmed and attributable primarily to estradiol. Impact Journals 2021-01-10 /pmc/articles/PMC7906196/ /pubmed/33428602 http://dx.doi.org/10.18632/aging.202280 Text en Copyright: © 2021 Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wang, Rangrang
Liu, Yuan
Sun, Hongze
Wang, Tao
Li, Changcan
Fan, Junwei
Wang, Zhaowen
Estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside
title Estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside
title_full Estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside
title_fullStr Estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside
title_full_unstemmed Estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside
title_short Estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside
title_sort estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906196/
https://www.ncbi.nlm.nih.gov/pubmed/33428602
http://dx.doi.org/10.18632/aging.202280
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