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RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome

Right ventricular (RV) dysfunction induced type II cardiorenal syndrome (CRS) has a high mortality rate, but little attention has been paid to this disease, and its unique molecular characteristics remain unclear. This study aims to investigate the transcriptomic expression profile in this disease a...

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Autores principales: Chen, Kaitong, Huang, Xiaoxia, Xie, Dongxiao, Shen, Mengjia, Lin, Hairuo, Zhu, Yingqi, Ma, Siyuan, Zheng, Cankun, Chen, Lu, Liu, Yameng, Liao, Wangjun, Bin, Jianping, Liao, Yulin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906202/
https://www.ncbi.nlm.nih.gov/pubmed/33494070
http://dx.doi.org/10.18632/aging.202385
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author Chen, Kaitong
Huang, Xiaoxia
Xie, Dongxiao
Shen, Mengjia
Lin, Hairuo
Zhu, Yingqi
Ma, Siyuan
Zheng, Cankun
Chen, Lu
Liu, Yameng
Liao, Wangjun
Bin, Jianping
Liao, Yulin
author_facet Chen, Kaitong
Huang, Xiaoxia
Xie, Dongxiao
Shen, Mengjia
Lin, Hairuo
Zhu, Yingqi
Ma, Siyuan
Zheng, Cankun
Chen, Lu
Liu, Yameng
Liao, Wangjun
Bin, Jianping
Liao, Yulin
author_sort Chen, Kaitong
collection PubMed
description Right ventricular (RV) dysfunction induced type II cardiorenal syndrome (CRS) has a high mortality rate, but little attention has been paid to this disease, and its unique molecular characteristics remain unclear. This study aims to investigate the transcriptomic expression profile in this disease and identify key RNA pairs that regulate related molecular signaling networks. We established an RV dysfunction-induced type II CRS mouse model by pulmonary artery constriction (PAC). PAC mice developed severe RV hypertrophy and fibrosis; renal atrophy and dysfunction with elevated creatinine were subsequently observed. Expression profiles in RV and kidney tissues were obtained by whole transcriptome sequencing, revealing a total of 741 and 86 differentially expressed (DE) mRNAs, 159 and 29 DEmiRNAs and 233 and 104 DEcircRNAs between RV and kidney tissue, respectively. Competing endogenous RNA (ceRNA) networks were established. A significant alteration in proliferative, fibrotic and metabolic pathways was found based on GO and KEGG analyses, and the network revealed key ceRNA pairs, such as novel_circ_002631/miR-181a-5p/Creb1 and novel_circ_002631/miR-33-y/Kpan6. These findings indicate that significantly dysregulated pathways in RV dysfunction induced type II CRS include Ras, PI3K/Akt, cGMP-PKG pathways, and thyroid metabolic pathways. These ceRNA pairs can be considered potential targets for the treatment of type II CRS.
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spelling pubmed-79062022021-03-04 RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome Chen, Kaitong Huang, Xiaoxia Xie, Dongxiao Shen, Mengjia Lin, Hairuo Zhu, Yingqi Ma, Siyuan Zheng, Cankun Chen, Lu Liu, Yameng Liao, Wangjun Bin, Jianping Liao, Yulin Aging (Albany NY) Research Paper Right ventricular (RV) dysfunction induced type II cardiorenal syndrome (CRS) has a high mortality rate, but little attention has been paid to this disease, and its unique molecular characteristics remain unclear. This study aims to investigate the transcriptomic expression profile in this disease and identify key RNA pairs that regulate related molecular signaling networks. We established an RV dysfunction-induced type II CRS mouse model by pulmonary artery constriction (PAC). PAC mice developed severe RV hypertrophy and fibrosis; renal atrophy and dysfunction with elevated creatinine were subsequently observed. Expression profiles in RV and kidney tissues were obtained by whole transcriptome sequencing, revealing a total of 741 and 86 differentially expressed (DE) mRNAs, 159 and 29 DEmiRNAs and 233 and 104 DEcircRNAs between RV and kidney tissue, respectively. Competing endogenous RNA (ceRNA) networks were established. A significant alteration in proliferative, fibrotic and metabolic pathways was found based on GO and KEGG analyses, and the network revealed key ceRNA pairs, such as novel_circ_002631/miR-181a-5p/Creb1 and novel_circ_002631/miR-33-y/Kpan6. These findings indicate that significantly dysregulated pathways in RV dysfunction induced type II CRS include Ras, PI3K/Akt, cGMP-PKG pathways, and thyroid metabolic pathways. These ceRNA pairs can be considered potential targets for the treatment of type II CRS. Impact Journals 2021-01-20 /pmc/articles/PMC7906202/ /pubmed/33494070 http://dx.doi.org/10.18632/aging.202385 Text en Copyright: © 2021 Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Chen, Kaitong
Huang, Xiaoxia
Xie, Dongxiao
Shen, Mengjia
Lin, Hairuo
Zhu, Yingqi
Ma, Siyuan
Zheng, Cankun
Chen, Lu
Liu, Yameng
Liao, Wangjun
Bin, Jianping
Liao, Yulin
RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome
title RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome
title_full RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome
title_fullStr RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome
title_full_unstemmed RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome
title_short RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome
title_sort rna interactions in right ventricular dysfunction induced type ii cardiorenal syndrome
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906202/
https://www.ncbi.nlm.nih.gov/pubmed/33494070
http://dx.doi.org/10.18632/aging.202385
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