ALKBH5-mediated m(6)A demethylation of FOXM1 mRNA promotes progression of uveal melanoma

In this study, we found that ALKBH5, a key component of the N(6)-methyladenosine (m(6)A) methyltransferase complex, was significantly elevated in uveal melanoma (UM) cell lines and that ALKBH5 downregulation inhibited tumor growth in vivo. High ALKBH5 expression predicted worse outcome in patients w...

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Detalles Bibliográficos
Autores principales: Hao, Lili, Yin, Jiayang, Yang, Hong, Li, Chaoxuan, Zhu, Linxin, Liu, Lian, Zhong, Jingxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906204/
https://www.ncbi.nlm.nih.gov/pubmed/33428593
http://dx.doi.org/10.18632/aging.202371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7906204/
https://www.ncbi.nlm.nih.gov/pubmed/33428593
http://dx.doi.org/10.18632/aging.202371

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